Efficacy of botulinum toxin A for the treatment of hemiparesis in adults with chronic upper limb spasticity

The Pan African Medical Journal
Sameh GhroubiMohamed Habib Elleuch

Abstract

this study aimed to evaluate the effectiveness of botulinum toxin A (BoNT-A) injection in hemiparetic patients with chronic spasticity in the upper limb resulting from stroke or traumatic brain injury. we conducted a retrospective study including 45 patients seen, in our department of Physical Medicine and Rehabilitation, between January 2014 and December 2016. All patients received an injection of BoNT-A (Dysport, 100 U/ml). Affected upper-extremity muscles could be injected as per the investigator's discretion to a maximum total dose of 1000 U. We evaluated muscle tone using Modified Ashworth Scale (MAS). Functional disability was assessed using Modified Frenchay Scale (MFS), Nine Hole Peg Test (NHPT) and Barthel Index (BI). Quality of life (QoL) was assessed using the 36-Item Short Form Health Survey (SF-36). The achievement of treatment goal was assessed by the Goal Attainment Scaling (GAS). patients decreased their MAS score over the first and the third months (p<0.05). MFS showed improvement at 1 month after injection with a median change from baseline of 8 (range: 1-16; p<0.001). The change from baseline ranged from 0 to 5 points for NHPT at 1 month after injection (p< 0.001). This functional improvement was maintained t...Continue Reading

References

Jan 4, 2001·American Journal of Physical Medicine & Rehabilitation·C E LevyD W Chakeres
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A M BakheitL Coxon
Apr 17, 2002·Journal of Neurology·Marc RousseauxJérome Froger
Jan 3, 2003·American Journal of Physical Medicine & Rehabilitation·Stephen J PageSue Ann Sisto
Aug 21, 2003·Annales de réadaptation et de médecine physique : revue scientifique de la Société française de rééducation fonctionnelle de réadaptation et de médecine physique·M RousseauxO Kozlowski
Apr 13, 2005·Disability and Rehabilitation·A Suputtitada, N C Suwanwela
Apr 26, 2005·Annales de réadaptation et de médecine physique : revue scientifique de la Société française de rééducation fonctionnelle de réadaptation et de médecine physique·A-L FerrapieI Richard
May 7, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·J SlawekD Reclawowicz
May 24, 2005·Current Opinion in Pharmacology·Cesare Montecucco, Jordi Molgó
Jan 31, 2009·Clinical Rehabilitation·Lynne Turner-Stokes
Mar 6, 2009·Neurorehabilitation and Neural Repair·Hui-Mei ChenChing-Lin Hsieh
Mar 5, 2011·Stroke; a Journal of Cerebral Circulation·Terence J QuinnDavid J Stott
Mar 19, 2011·Stroke; a Journal of Cerebral Circulation·Lisa C ShawUNKNOWN BoTULS Investigators
Jul 17, 2012·Annals of Physical and Rehabilitation Medicine·M GuermaziM H Elleuch
Dec 1, 1968·Community Mental Health Journal·T J Kiresuk, R E Sherman
Sep 1, 2015·Lancet Neurology·Jean-Michel GraciesUNKNOWN International AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

SPSS
MAS

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation
Toru TakekawaMasahiro Abo
© 2022 Meta ULC. All rights reserved