Efficacy of botulinum toxin A injections in the urethral sphincter in patients with difficulties to perform self-intermittent catherization

Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
T HonoreG Amarenco

Abstract

To evaluate safety and efficacy of botulinum toxin A injections in the urethral striated sphincter in patients with difficulties to perform self-intermittent catherization. In this prospective study, 12 patients suffering from upper motor neuron diseases (8 multiple sclerosis, 2 myelitis, 1 brain injury, 1 multi system atrophy) and with difficulties to perform self-intermittent catherization, defined by a ICDQ score>1 (Intermittent Catheterization Difficulty Questionnaire) have had injections of 100U BOTOX® under EMG guidance in the urethral striated sphincter, for a total of 15 injections. Evaluations consisted of two questionnaires (ICDQ and PGI-A, Patient Global Improvement) 30 days after the injection. 30 days after the injection, ICDQ was improved with a mean decrease of the total score of 7.8 (SD=5.9, P<0,001). In the same manner, all the patients were improved with a mean PGI-A score of 2.3. In 73.3 % of cases, the PGI-A score was equal to 2 (improvement=much better), and in 20 % it was equal to 3 (improvement=a little better). Botulinum toxin A injections in the urethral striated sphincter in patients with difficulties to perform self-intermittent catherization seem to safe and effective. 4.

Citations

May 22, 2019·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·N TurmelG Amarenco
Jan 10, 2019·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·X BiardeauUNKNOWN pour Groupe de recherche appliquée à la pathologie pelvi-périnéale des personnes âgées (GRAPPPA)
Apr 12, 2021·Archives of Physical Medicine and Rehabilitation·Xue WangQing Zhang

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