Efficacy of butyrate analogues in HT-29 cancer cells

Clinical and Experimental Pharmacology & Physiology
Cheng C OoiRichard J Head

Abstract

1. Butyrate is a well known product of starch fermentation by colonic bacteria and is of interest owing to its ability to induce in vitro apoptosis and cell differentiation, as well as to inhibit cell growth in colorectal and other cancer cells. Synthetic analogues of butyrate may also possess cellular activities in a variety of cultured cells. The aim of the present study was to evaluate the effects of butyrate analogues on apoptosis, proliferation and histone deacetylase (HDAC) activity in HT-29 colorectal cancer cells. In addition, the effects of these analogues on lactate dehydrogenase leakage, as a measure of non-specific cytotoxicity, were evaluated in HT-29 cells. 2. Of the 26 analogues examined, four (propionate, 4-benzoylbutyrate, 4-(4-aminophenyl)butyrate and benzyloxyacetate) exhibited comparable effects to butyrate. Interestingly, no activity was noted for compounds carrying amino, hydroxyl or methyl substitutions at the 2-, 3- or 4-position of the aliphatic moiety of butyrate. 3. In conclusion, chemical changes to the structure of butyrate can significantly modify the biological activity assayed in HT-29 colorectal cancer cells in vitro.

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Citations

Aug 27, 2013·Chemistry and Physics of Lipids·S MolinaG Reglero
Jun 9, 2012·The British Journal of Nutrition·Kim Y C FungDavid L Topping
Jun 28, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·M Andrea Azcárate-PerilJosé M Bruno-Bárcena
Sep 17, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lu YuanJiru Xu

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