Efficacy of Butyric and Valeric Acid Esters in a Necrotic Enteritis Challenge Model.

Avian Diseases
C HofacreEric Clanton

Abstract

Restrictions on the use of antibiotics in poultry production have increased interest in nonantibiotic alternatives to control necrotic enteritis (NE). Volatile fatty acids, and in particular butyric acid preparations, have shown potential as aids in controlling NE. Valeric acid compounds may be a new additional alternative. This series of three trials compared the effects of tributyrin, monovalerin, which is an organic acid mixture, and bacitracin in a NE challenge model consisting of challenge with coccidiosis followed by Clostridium perfringens. Trial 1 was a pen trial comparing tributyrin at 0.5 kg/metric ton continuously in the feed, a proprietary organic acid blend at 1 kg per 1000 L as a metaphylactic treatment in the water, and bacitracin in the feed at 55 g/metric ton. Tributyrin and the organic acid mixture were at least as effective as bacitracin in controlling the growth- and efficiency-suppressing effects of the NE challenge, and the organic acid mixture reduced NE lesion scores. None of the treatments reduced mortality. Trial 2 was a battery study comparing monovalerin at 1.5 kg/metric ton and bacitracin in the feed. Both interventions provided significant control of both clinical and subclinical NE, with bacitraci...Continue Reading

References

Mar 15, 2005·Avian Pathology : Journal of the W.V.P.A·Filip Van ImmerseelRichard Ducatelle
Jun 18, 2005·Letters in Applied Microbiology·E SkrivanováJ Kanka
Jan 5, 2006·Applied and Environmental Microbiology·I GantoisF Van Immerseel
Jun 7, 2006·Avian Pathology : Journal of the W.V.P.A·F Van ImmerseelR Ducatelle
Aug 9, 2007·International Journal of Systematic and Evolutionary Microbiology·Takao IinoShigeaki Harayama
Nov 2, 2007·Alimentary Pharmacology & Therapeutics·H M HamerR-J Brummer
Apr 13, 2010·The Veterinary Journal·Gerard HuyghebaertFilip Van Immerseel
Oct 13, 2010·Nutrition Research Reviews·P GuilloteauF Van Immerseel

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