Efficacy of calcium channel blocker in the secondary prevention of myocardial infarction--retrospective analysis of the 10-year prognosis or coronary thrombolysis-treated patients

Circulation Journal : Official Journal of the Japanese Circulation Society
Shigemasa TaniKatsuo Kanmatsuse

Abstract

Calcium channel blockers (CCBs) may have a positive influence on the long-term prognosis of Japanese patients with ischemic heart disease. The effect of nifedipine-retard (NR) (n=202) compared with that of non-CCB treatment (n=92) on the secondary prevention of myocardial infarction (MI) was retrospectively investigated in patients who had survived acute MI between 1987 and 1996. The primary endpoint was the occurrence of cardiac death or non-fatal MI. The median follow-up was 6.3+/-2.4 years. The incidence of cardiac events was 8.9% in the NR group and 14.1% in the non-CCBs group (p=0.14, odds ratio (OR): 0.584, 95% confidence interval (CI): 0.286-1,193). However, subanalysis revealed that NR significantly reduced the incidence of cardiac events in patients aged less than 55 years (4.2 vs 18.2%, p=0.016, OR: 0.180, 95%CI: 0.045-0.721) and those who did not smoke (8.6 vs 16.4%, p=0.048, OR: 0.462, 95%CI: 0.203-0.999). Although this was a retrospective analysis, it showed that NR did not cause an increase in the incidence of cardiac events in post-MI patients; it even prevented cardiac events, especially in those who were less than 55 years of age and in non-smokers, suggesting the potential usefulness of CCBs in the secondary p...Continue Reading

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Citations

Feb 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Ming-Jui HungWen-Jin Cherng
Oct 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Takaaki TaniwaKinji Ishikawa
Nov 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Takahide KohroUNKNOWN JCAD Investigators
Mar 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Tetsuya IshikawaSatoshi Kurihara

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