Abstract
Triptans are usually administered for migraine, but cannot be given to patients with malfunctioning cardiac or cerebral vascular systems, which commonly accompany hypertension. This article focuses on 8 cases in which treatment with candesartan was successful in reducing both the incidence and severity of headache in hypertensive patients with migraine. The cases reported in this article showed a mean improvement in Migraine Disability Assessment score from 29.4 to 9 points and in blood pressure from 154.9/90.4 to 129.5/81.9mmHg, suggesting that candesartan is an extremely attractive option for the treatment of migraine. Although recent studies have reported the efficacy of candesartan for treating migraine, there has been no description of its potential advantages over other prophylactic drugs. The present study included patients who could not tolerate triptans for whom triptans were contraindicated, several patients for whom other migraine prophylactic drugs showed little or no effect, and one patient for whom candesartan was prescribed initially for hypertension, but was also found to be therapeutic for migraines. Thus candesartan is considered to be a unique, attractive choice of prophylactic agent for migraine complicated ...Continue Reading
References
Oct 1, 1992·Cephalalgia : an International Journal of Headache·M J HoffertR Kanter
Jan 1, 1992·Life Sciences·K MizunoS Fukuchi
Jun 11, 1988·Lancet·F Wells
Jan 1, 1985·European Neurology·G C ManzoniA Solari
Nov 23, 1968·Lancet·G H Hall
Aug 1, 1984·Annals of Neurology·M A Moskowitz
May 30, 1998·Archives of Neurology·J F MeschiaJ Biller
Jan 5, 2001·BMJ : British Medical Journal·H SchraderG Bovim
Jan 11, 2001·Drugs·P Tfelt-HansenP R Saxena
Mar 29, 2001·Journal of Molecular and Cellular Cardiology·M YoshiyamaJ Yoshikawa
May 1, 2001·Journal of Hypertension·H ItoT Suzuki
Dec 31, 2002·JAMA : the Journal of the American Medical Association·Erling TronvikGunnar Bovim
Jan 15, 2003·Current Pain and Headache Reports·Nestor C Punay, James R Couch
Jan 22, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Giuseppe NappiGrazia Sances
Jul 17, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoru MurayamaMitsuru Adachi
Jul 31, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Trefor Morgan
Nov 5, 2003·Journal of Hypertension·Wolf GrothJuraj Culman
Nov 11, 2003·European Journal of Heart Failure·Alison P ColettaAndrew L Clark
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuaki DohiRyuzo Ueda
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroshi Hirose, Ikuo Saito
Jan 1, 2000·Blood Pressure·Faiez Zannad
Citations
Apr 25, 2012·Indian Journal of Pharmacology·Ruchika Nandha, Harpal Singh
Apr 15, 2014·Current Pain and Headache Reports·Erling Tronvik, Lars Jacob Stovner
Aug 6, 2009·Progress in Neurobiology·Francesca GallettiPaola Sarchielli
Oct 2, 2009·The Journal of Headache and Pain·Lars Jacob StovnerKnut Hagen
Jan 12, 2010·The Journal of Headache and Pain·Kirsti Haaland
Oct 17, 2006·Headache·Werner J BeckerCarin Binder
Feb 28, 2008·Headache·Randolph W EvansDhirendra Bana
Jul 22, 2014·Headache·Derek Neilson, Vincent T Martin
Mar 24, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideo IkedaKoichi Node
Jun 10, 2011·Expert Opinion on Pharmacotherapy·Alexander JoostPeter Walter Radke
Jun 9, 2005·Expert Review of Neurotherapeutics·Min-Suk YoonVolker Limmroth
Jan 30, 2007·Cephalalgia : an International Journal of Headache·J HaanM D Ferrari
Dec 18, 2013·Cephalalgia : an International Journal of Headache·Lars J StovnerKnut Hagen
Jan 21, 2010·The Annals of Pharmacotherapy·Barry J GalesMark A Gales
Jun 17, 2020·Journal of Neurology·Roberta MessinaPeter J Goadsby
Feb 17, 2021·Scientific Reports·Carmen Sánchez-RodríguezDavid García-Azorín
Aug 12, 2021·British Journal of Pharmacology·Farzin ZobdehJessica Mwinyi