PMID: 15253110Jul 16, 2004Paper

Efficacy of candesartan in the treatment of migraine in hypertensive patients

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Kiyoshi Owada

Abstract

Triptans are usually administered for migraine, but cannot be given to patients with malfunctioning cardiac or cerebral vascular systems, which commonly accompany hypertension. This article focuses on 8 cases in which treatment with candesartan was successful in reducing both the incidence and severity of headache in hypertensive patients with migraine. The cases reported in this article showed a mean improvement in Migraine Disability Assessment score from 29.4 to 9 points and in blood pressure from 154.9/90.4 to 129.5/81.9mmHg, suggesting that candesartan is an extremely attractive option for the treatment of migraine. Although recent studies have reported the efficacy of candesartan for treating migraine, there has been no description of its potential advantages over other prophylactic drugs. The present study included patients who could not tolerate triptans for whom triptans were contraindicated, several patients for whom other migraine prophylactic drugs showed little or no effect, and one patient for whom candesartan was prescribed initially for hypertension, but was also found to be therapeutic for migraines. Thus candesartan is considered to be a unique, attractive choice of prophylactic agent for migraine complicated ...Continue Reading

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Citations

Apr 25, 2012·Indian Journal of Pharmacology·Ruchika Nandha, Harpal Singh
Apr 15, 2014·Current Pain and Headache Reports·Erling Tronvik, Lars Jacob Stovner
Aug 6, 2009·Progress in Neurobiology·Francesca GallettiPaola Sarchielli
Oct 2, 2009·The Journal of Headache and Pain·Lars Jacob StovnerKnut Hagen
Jan 12, 2010·The Journal of Headache and Pain·Kirsti Haaland
Oct 17, 2006·Headache·Werner J BeckerCarin Binder
Feb 28, 2008·Headache·Randolph W EvansDhirendra Bana
Mar 24, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideo IkedaKoichi Node
Jun 10, 2011·Expert Opinion on Pharmacotherapy·Alexander JoostPeter Walter Radke
Jun 9, 2005·Expert Review of Neurotherapeutics·Min-Suk YoonVolker Limmroth
Jan 30, 2007·Cephalalgia : an International Journal of Headache·J HaanM D Ferrari
Jun 17, 2020·Journal of Neurology·Roberta MessinaPeter J Goadsby
Feb 17, 2021·Scientific Reports·Carmen Sánchez-RodríguezDavid García-Azorín
Aug 12, 2021·British Journal of Pharmacology·Farzin ZobdehJessica Mwinyi

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