Efficacy of carnitine in treatment of tinnitus: evidence from audiological and MRI measures-a case study

Journal of the American Academy of Audiology
Kamakshi V GopalHanzhang Lu

Abstract

Tinnitus, or ringing in the ears, is an extremely common ear disorder. However, it is a phenomenon that is very poorly understood and has limited treatment options. The goals of this case study were to identify if the antioxidant acetyl-L-carnitine (ALCAR) provides relief from tinnitus, and to identify if subjective satisfaction after carnitine treatment is accompanied by changes in audiological and imaging measures. Case Study. A 41-yr-old female with a history of hearing loss and tinnitus was interested in exploring the benefits of antioxidant therapy in reducing her tinnitus. The patient was evaluated using a standard audiological/tinnitus test battery and magnetic resonance imaging (MRI) recordings before carnitine treatment. After her physician's approval, the patient took 500 mg of ALCAR twice a day for 30 consecutive days. The audiological and MRI measures were repeated after ALCAR treatment. Pure-tone audiometry, tympanometry, distortion-product otoacoustic emissions, tinnitus questionnaires (Tinnitus Handicap Inventory and Tinnitus Reaction Questionnaire), auditory brainstem response, functional MRI (fMRI), functional connectivity MRI, and cerebral blood flow evaluations were conducted before intake of ALCAR and were r...Continue Reading

Citations

May 5, 2016·Journal of Audiology & Otology·Sema KoçNurten Aksoy
Aug 9, 2017·Frontiers in Aging Neuroscience·Victoria MilloyAmineh Koravand
Nov 23, 2018·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Mustafa Celik, İsmail Koyuncu
Oct 11, 2020·Biological Trace Element Research·Nihal Efe AtilaEbubekir Bakan
Aug 19, 2021·CoDAS·Renata da SilvaMaria Cecília Martinelli Iório

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