PMID: 16517821Mar 7, 2006Paper

Efficacy of ceftiofur and flunixin in the early treatment of bronchopneumonia in weaners

The Veterinary Record
David J HalloyPascal G Gustin

Abstract

Three groups of five pigs were inoculated intratracheally with Escherichia coli lipopolysaccharides, and 24 hours later with 10 x 10(9) colony-forming units of a non-toxigenic strain of Pasteurella multocida type A; a fourth group was left uninoculated as controls. The three inoculated groups received either no treatment (positive controls), or were treated with 3 mg/kg ceftiofur intramuscularly once a day for five consecutive days, either alone or combined with 2 mg/kg flunixin intramuscularly once a day for three consecutive days. The sustained coughing and hyperthermia recorded in the positive controls disappeared after two days and three days of treatments, respectively, in the treated animals, and the reductions in daily weight gain and changes in breathing pattern observed in the controls were not observed in the treated animals. There were no significant differences between the pigs treated with ceftiofur alone or ceftiofur combined with flunixin. In the positive controls, the number of inflammatory cells in samples of bronchoalveolar lavage fluid continued to increase up to 15 days after inoculation, whereas in the treated animals there were similar increases at six days but the numbers had decreased to baseline levels ...Continue Reading

Citations

Dec 17, 2008·The Journal of Antimicrobial Chemotherapy·Angkana TantituvanontDahrit Nilubol
Mar 3, 2010·International Immunopharmacology·Xiao ChuXuming Deng
Nov 2, 2018·The Journal of Veterinary Medical Science·Jincheng XiongYinsheng Qiu
May 2, 2019·The Veterinary Record·Alexandra SchoosDominiek Gd Maes

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