Efficacy of ciprofloxacin alone and in combination with azlocillin in experimental endocarditis due to Pseudomonas aeruginosa

Infection
C ThauvinJ F Lemeland

Abstract

The efficacy of ciprofloxacin alone and in combination with azlocillin was compared with that of azlocillin plus tobramycin in a rat model of aortic valve endocarditis due to Pseudomonas aeruginosa. MICs against the infecting strain of ciprofloxacin, azlocillin and tobramycin were 0.125, 8, and 0.5 mg/l, respectively. Antimicrobials were administered 24 h after bacterial challenge and for six days. Mean peak/trough serum levels for ciprofloxacin (50 mg/kg i.v. q 12 h), azlocillin (500 mg/kg i.v. q 12 h) and tobramycin (6.5 mg/kg i.v. q 12 h) were: 10.5/0.2, 386/less than 16, and 6.2/less than 0.6 mg/l, respectively. Ciprofloxacin alone was more effective than the combination azlocillin-tobramycin in increasing survival (p less than 0.05), sterilizing blood (p less than 0.05) and valves (p less than 0.001), and in reducing bacterial titers in vegetations (p less than 0.001). Ciprofloxacin-azlocillin combination was not more effective than ciprofloxacin alone. Drug resistance was not encountered in post-treatment isolates with any therapy regimen.

References

Mar 1, 1978·Infection and Immunity·J Santoro, M E Levison
Sep 1, 1985·European Journal of Cancer & Clinical Oncology·J J KavanaghG P Bodey
Mar 1, 1986·Antimicrobial Agents and Chemotherapy·B KemmerichJ E Pennington
Apr 1, 1986·European Journal of Clinical Microbiology·H GiamarellouG K Daikos
Apr 1, 1986·European Journal of Clinical Microbiology·F FollathH Reber
May 1, 1986·The Journal of Antimicrobial Chemotherapy·A S BayerK S Kim
Nov 1, 1986·The Journal of Antimicrobial Chemotherapy·S H Zinner, M N Dudley
Nov 1, 1986·The Journal of Antimicrobial Chemotherapy·C J HackbarthM A Sande
Feb 1, 1987·Antimicrobial Agents and Chemotherapy·C ThauvinR C Moellering
Apr 1, 1988·The American Journal of Medicine·G L DaikosE Fosslien
Feb 1, 1985·The Journal of Infectious Diseases·C W Norden, E Shinners
Mar 1, 1986·Antimicrobial Agents and Chemotherapy·A M ShiblM A Sande
Nov 1, 1986·The Journal of Antimicrobial Chemotherapy·L R Peterson
Mar 1, 1983·Reviews of Infectious Diseases·G P BodeyL Jadeja
Mar 1, 1983·Reviews of Infectious Diseases·M P Reyes, A M Lerner
May 1, 1983·The Journal of Antimicrobial Chemotherapy·H C Neu
Oct 1, 1984·Antimicrobial Agents and Chemotherapy·J E RudinE M Shinners
Mar 1, 1984·Antimicrobial Agents and Chemotherapy·G M EliopoulosR C Moellering
Jan 1, 1980·Progress in Cardiovascular Diseases·P S CohenL Weinstein
Nov 1, 1980·Antimicrobial Agents and Chemotherapy·R D PearsonS W Chapman
Mar 11, 1985·Physical Review Letters·C BaktashD G Sarantites

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.