Efficacy of clevidipine in controlling perioperative hypertension in neurosurgical patients: initial single-center experience

Journal of Neurosurgical Anesthesiology
Alex BekkerMitchell Lee

Abstract

Acute blood pressure (BP) elevations in neurosurgical patients are associated with serious neurologic, cardiovascular, or surgical site complications. Clevidipine, an ultra-short-acting dihydropyridine calcium antagonist, has been shown to be efficacious and safe for acute hypertension in cardiac surgery. This study assessed the efficacy and safety of clevidipine in controlling perioperative hypertension in the neurosurgical setting. Patients scheduled for intracranial surgery were prospectively enrolled after giving consent. Clevidipine (0.5 mg/mL in 20% lipid solution, which was to be initiated at 10 mg/h and titrated to effect) was administered as the primary antihypertensive agent for perioperative hypertension, with target BPs of less than 130 mm Hg. Other vasoactive drugs were administered as needed for treating systolic BP (SBP) less than 90 mm Hg or greater than 130 mm Hg. The primary study endpoint was the proportion of patients not requiring rescue antihypertensives to maintain target SBP (<130 mm Hg). Twenty-two patients were enrolled. One patient did not require antihypertensive therapy. Seventeen patients (17 of 21, 81%) were treated with clevidipine alone; one received clevidipine in the postanesthesia care unit o...Continue Reading

Associated Clinical Trials

Sep 27, 2013·John Bebawy, John Bebawy

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Citations

Sep 23, 2014·Revista española de anestesiología y reanimación·A Zuleta-AlarcónS Bergese
Mar 11, 2011·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak, William L Lanier
Jan 19, 2012·Expert Opinion on Pharmacotherapy·Ilse M Espina, Joseph Varon
Sep 16, 2014·Frontiers in Pharmacology·Lakshmi N KurnutalaSergio D Bergese
Sep 3, 2021·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Bo XuGaorui Tang

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