Efficacy of clindamycin/primaquine versus trimethoprim/sulfamethoxazole in primary treatment of Pneumocystis carinii pneumonia

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
B RufH D Pohle

Abstract

Mild to moderately severe Pneumocystis carinii pneumonia in patients with AIDS was treated in a clinical trial with a combination regimen of primaquine and clindamycin, and the efficacy of this regimen was compared with that of the conventional treatment regimen of trimethoprim/sulfamethoxazole. The results revealed that primaquine/clindamycin appears to be an equally effective alternative to trimethoprim/sulfamethoxazole. The spectrum of side-effects was similar for the two regimens; side-effects occurred with equal frequency but appeared to be less severe in patients given primaquine/clindamycin. Because therapy with primaquine and clindamycin was limited to patients with mild to moderate Pneumocystis carinii pneumonia, studies with this regimen in more severe cases are warranted.

References

Jan 1, 1991·International Journal of Antimicrobial Agents·I Varthalitis, F Meunier
Jul 1, 1997·Critical Care Clinics·M J CowanS J Levine
Feb 4, 1998·Critical Care Clinics·C F Decker, H Masur
Oct 1, 1993·Antimicrobial Agents and Chemotherapy·S F QueenerJ W Smith
Aug 8, 2017·Expert Review of Anti-infective Therapy·Yu-Shan HuangChien-Ching Hung

Citations

Apr 1, 1990·Antimicrobial Agents and Chemotherapy·R T Davey, H Masur
Jan 1, 1989·The Journal of Antimicrobial Chemotherapy·B G Gazzard
Jul 1, 1988·The Journal of Infectious Diseases·J A Kovacs, H Masur
Jun 1, 1988·Antimicrobial Agents and Chemotherapy·S F QueenerJ W Smith
Jun 1, 1974·Antimicrobial Agents and Chemotherapy·F G Araujo, J S Remington

Related Concepts

Trimethoprim
Pneumocystis Infections
Polychemotherapy
Primacin
Dalacin C
Pneumocystis Jiroveci Pneumonia
Pneumonia
Metomide
Primaquine
Clinical Trial [Publication Type]

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