Efficacy of cold atmospheric plasma versus diclofenac 3% gel in patients with actinic keratoses: a prospective, randomized, and rater-blinded study (ACTICAP)

Journal of the European Academy of Dermatology and Venereology : JEADV
F KochA Roesch

Abstract

Actinic keratoses (AK) represent the most common skin malignancy worldwide and are considered the earliest stage in cutaneous squamous cell carcinoma development. Conventional therapies bear significant side effects and/or are limited to small treatment areas. Thus, there is a continuing need for nontoxic lesion- and field-directed treatment options for extensive AK. Cold atmospheric plasma (CAP) is a partially ionized gas containing a mixture of reactive oxygen and nitrogen species. In addition to its well-documented antimicrobial properties, growing evidence points to antitumor effects 1 . Anecdotal observations suggest promising clinical response of AK treated with various CAP devices 2, 3 . However, confirmatory clinical studies comparing the efficacy of CAP with conventional therapies are lacking.

References

Aug 9, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Matthias SchusterHans-Robert Metelmann
Jan 17, 2017·Journal of the American Academy of Dermatology·Peter C FriedmanAlexander Fridman
Jul 12, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·M WirtzA Roesch

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Citations

Jan 13, 2021·American Journal of Clinical Dermatology·Peter C Friedman

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