Abstract
In war, uncomplicated penetrating injuries to limbs require evacuation to a surgical facility. A delay is inevitable between injury and definitive surgical treatment. This paper describes an experimental model that has been developed to assess the efficacy of antibiotics in such war wounds; the aim is to develop a treatment protocol to prevent the development of infection before casualties reach a surgical facility. The model is described in detail. Its use to determine efficacy of an antibiotic regimen, and the consequences of delay in the initial administration of antibiotic, are summarized. Streptococcus Lancefield Group L (Strep L) is a pig pathogen analogous to the Streptococcus pyogenes Lancefield Group A in man. The latter is perceived as a major threat to the casualty with a neglected penetrating wound. Strep L caused reproducible infection in a low-energy-transfer fragment wound to a pig thigh. When the wound was observed over a period of 7 days, the only other organisms that appeared consistently were pig pathogenic and nonpathogenic staphylococcal species. Despite the site of the wound, fecal organisms were not observed to colonize the wound significantly, neither were they a cause of early wound infection. The treat...Continue Reading
References
Sep 1, 1978·The Journal of Trauma·R M Hardaway
Dec 1, 1975·The Surgical Clinics of North America·T J Krizek, M C Robson
Nov 1, 1975·American Journal of Surgery·T J Krizek, M C Robson
Sep 1, 1991·The British Journal of Surgery·T J SpaldingK M Stephens
Jan 1, 1988·The Journal of Trauma·F A el-Ezaby, W A el-Shorbagy
Apr 1, 1988·The Journal of Trauma·J Rautio, P Paavolainen
Jan 1, 1968·The British Journal of Surgery·M S Owen-Smith, J M Matheson
Dec 3, 1953·The New England Journal of Medicine·E J PULASKI
Nov 1, 1938·The Journal of Hygiene·A A MilesJ O Irwin
Citations
Mar 14, 2002·Injury·D K NikolićM Mladenović
Sep 7, 1999·Injury·D NikolićM Mladenović
May 26, 1999·Injury·D NikolićM Mladenović
Apr 25, 2000·Injury·D NikolićM Mladenović
Dec 15, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W G P EardleyJ C Clasper
May 31, 2013·Journal of the Royal Army Medical Corps·William G P EardleyJ C Clasper
Jun 2, 2014·Travel Medicine and Infectious Disease·Audrey MérensRemy Michel
Mar 17, 2004·The Journal of Urology·Richard A Santucci, Yao-Jen Chang
Aug 17, 2014·International Journal of Oral and Maxillofacial Surgery·P K StefanopoulosK Filippakis
Sep 26, 2000·The Journal of Trauma·R L MabryJ H Hagmann
Sep 4, 2004·The Journal of Trauma·Steven J CyrGary E Benedetti
Jun 22, 2010·Biopolymers·Eszter OstorhaziLaszlo Otvos
Jan 25, 2008·Journal of the Royal Army Medical Corps·D S Jackson
Dec 21, 2006·Journal of the Royal Army Medical Corps·D E HinsleyJ S Clasper
Apr 20, 2010·Journal of the Royal Army Medical Corps·A RamasamyJ C Clasper
Dec 19, 2008·Journal of the Royal Army Medical Corps·N TaiP Parker
Dec 19, 2008·Journal of the Royal Army Medical Corps·P J Parker
Mar 23, 2019·Military Medicine·Yuval GlickTal Brosh
Sep 20, 2011·The Journal of Trauma·Duane R HospenthalUNKNOWN Surgical Infection Society
Sep 20, 2011·The Journal of Trauma·Clinton K MurrayUNKNOWN Prevention of Combat-Related Infections Guidelines Panel
Aug 10, 2011·The Journal of Trauma·Clinton K MurrayFrank K Butler
Jan 6, 2012·The Journal of Bone and Joint Surgery. British Volume·J G Penn-BarwellJ C Wenke
Apr 9, 2020·Expert Review of Anti-infective Therapy·Tania Nawfal DagherJean-Marc Rolain
Nov 24, 2004·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Dragan Nikolić