Efficacy of Different Compositions of Cerium Oxide Nanoparticles in Tumor-Stroma Interaction

Journal of Biomedical Nanotechnology
Maren Sack-ZschauerPeter Brenneisen

Abstract

The biomedical application of cerium oxide nanoparticles (nanoceria) is a focal point of research for a few years. The biochemical effects of nanoceria depend on various factors including particle size, oxidation state of cerium, oxygen vacancies on the surface, use of dispersants or coatings, pH and cell type. Due to their autocatalytic redox-activity, these particles are considered to act as a specific anti-cancer tool with less side effects on healthy cells and tissues, as the particles kill tumor cells, while protecting healthy cells from oxidative damage. In the present study, four different types of nanoceria were investigated with regard to their impact on biochemical parameters in vitro, which play a pivotal role in tumor-stroma interaction. The obtained data and presented in vitro test parameters will be helpful in designing nanoceria compositions, which are ideally suited for anticancer therapy, either as a 'stand alone drug' or in combination with other chemotherapeutics.

Citations

Nov 6, 2018·Journal of Nanobiotechnology·Izabela Sadowska-Bartosz, Grzegorz Bartosz
Oct 14, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Sushant SinghSudipta Seal
Apr 30, 2021·Journal of Biomaterials Applications·Sushant SinghSudipta Seal
Aug 24, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohd Aslam SaifiChandraiah Godugu

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