PMID: 9002080Jan 1, 1997Paper

Efficacy of different triglycerides in total parenteral nutrition for preventing atrophy of the gut in traumatized rats

JPEN. Journal of Parenteral and Enteral Nutrition
J Linseisen, G Wolfram

Abstract

The efficacy of different fat emulsions as components of a total parenteral nutrition (TPN) regimen on the integrity of the gut was assessed in traumatized rats. With the release of the short-chain fatty acids butyric or propionic acid during the hydrolysis of a structured triglyceride containing butyric acid (C4-L-C4-TG) or the beta-oxidation of nonanoic acid from trinonanoin (C9TG), respectively, the infusion of these two triglycerides was supposed to reveal positive effects against the TPN-induced atrophy of the intestine. After 3 days of fiber-free liquid diet, rats were traumatized (laparotomy) and catheterized. Afterwards they received equicaloric TPN that delivered 1008 kJ (241 kcal)/kg of body weight per day and 30% nonprotein calories as fat emulsion. The four fat emulsions tested in four groups of six animals contained either long-chain triglycerides (LCT), medium-chain triglycerides (MCT)-LCT (1:1), C9TG/LCT (1:1) or C4-L-C4-TG. Animals of a control group were infused with isovolemic 0.9% NaCl solution and were offered oral standard chow. After 7 days of MCT/LCT administration, the mass-to-length ratio of the total small bowel as well as the masses of mucosa/submucosa and muscularis/serosa in 10-cm segments of the di...Continue Reading

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Citations

Jul 26, 2005·European Journal of Nutrition·Helmut GrimmPeter Fürst
Aug 30, 2000·The Journal of Trauma·Y HarariF G Moody
Apr 13, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Richard J DeckelbaumYvon A Carpentier
Sep 4, 2009·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Terezie Tolar MosbyPaul B Pencharz
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·E LinS F Lowry
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·I E Dupont, Y A Carpentier

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