Efficacy of diltiazem in the treatment of diffuse oesophageal spasm

Alimentary Pharmacology & Therapeutics
J P DrenthL G Engels

Abstract

Calcium antagonist relax smooth muscle, a possible useful concept in treatment of diffuse oesophageal spasm. Therefore the effects of oral diltiazem (60 mg t.d.s.) and placebo were compared in eight patients with diffuse oesophageal spasm in a 10-week double-blind crossover study. The patients recorded the severity of chest pain and/or dysphagia in daily pain diaries using visual analogue scales. Chest pain index and dysphagia index were calculated by multiplying frequency with daily intensity of each individual symptom. When compared to placebo, diltiazem did not significantly change the overall dysphagia index and chest pain index. An individual sizeable reduction of dysphagia was attained on diltiazem in four out of six patients and in six out of eight patients suffering from chestpain. Side effects were not seen during diltiazem therapy. Diltiazem, in our study, did not yield in a significant improvement of symptoms in diffuse oesophageal spasm. Diltiazem, however, can offer relief in selected individual patients suffering from diffuse oesophageal spasm.

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Citations

May 4, 2006·Alimentary Pharmacology & Therapeutics·R Tutuian, D O Castell
Mar 28, 2008·Journal of Clinical Gastroenterology·Brian E Lacy, Kirsten Weiser
Mar 28, 2008·Journal of Clinical Gastroenterology·Ronnie Fass, Tomás Navarro-Rodriguez
Feb 27, 2015·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Yang Won Min, Poong-Lyul Rhee
Nov 8, 2014·Current Gastroenterology Reports·Miguel A ValdovinosEnrique Coss-Adame
Nov 26, 2015·Alimentary Pharmacology & Therapeutics·N GeorgeR Fass
Nov 15, 2011·Alimentary Pharmacology & Therapeutics·T HershcoviciR Fass
Jul 31, 2013·Current Gastroenterology Reports·Sami R Achem, Lauren B Gerson
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May 13, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M BashashatiM Storr
Nov 2, 2012·Journal of Pediatric Gastroenterology and Nutrition·John M RosenPaul E Hyman
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Aug 30, 2008·Disease-a-month : DM·Sami R Achem
Nov 26, 2008·Gastroenterology Clinics of North America·Sami R Achem

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