PMID: 3745714Sep 1, 1986Paper

Efficacy of diltiazem in two experimental feline models of sudden cardiac death

Journal of the American College of Cardiology
P J SchwartzG Zuanetti

Abstract

The potential role of calcium entry blockers in the prevention of life-threatening arrhythmias associated with acute myocardial ischemia and reperfusion is still controversial. In 98 anesthetized cats, the effect of diltiazem was examined in two experimental models. In protocol I, ventricular tachycardia or fibrillation was consistently induced by the interaction between a 2 minute coronary artery occlusion and a 30 second left stellate ganglion stimulation. After three trials under control conditions, if the same pattern of arrhythmia was induced, the drug under study was administered and three additional trials were performed. In 16 animals the administration of saline solution did not modify the pattern of arrhythmias. In contrast, diltiazem (0.1 mg/kg body weight plus 0.2 mg/kg per h) abolished both ventricular tachycardia and fibrillation that had occurred in 64 and 36%, respectively, of the cats in the control state. In protocol II, a 20 minute coronary artery occlusion was released in three groups; one served as the control group, one received diltiazem 15 minutes before occlusion and one received diltiazem 3 minutes before reperfusion. The incidence of reperfusion ventricular fibrillation was 62% (16 of 26) in the contr...Continue Reading

References

Jun 1, 1979·The American Journal of Cardiology·R WeishaarR J Bing
Jul 1, 1975·The American Journal of Cardiology·B R KliksJ A Abildskov
Jun 1, 1976·The American Journal of Cardiology·P J SchwartzA M Brown
Jan 1, 1985·Journal of Cardiovascular Pharmacology·A Zaza, P J Schwartz
May 1, 1985·American Heart Journal·G ZuanettiP J Schwartz
Jun 1, 1984·Journal of Molecular and Cellular Cardiology·A S Manning, D J Hearse
Jan 1, 1984·Annals of the New York Academy of Sciences·J A SalernoP Bobba
Jan 15, 1984·The American Journal of Cardiology·D C RussellM F Oliver
Jan 1, 1982·Annals of the New York Academy of Sciences·P J Schwartz, H L Stone

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Citations

Nov 1, 1990·Journal of the American College of Cardiology·E VanoliP J Schwartz
Mar 1, 1994·Pacing and Clinical Electrophysiology : PACE·E Vanoli, P B Adamson
Sep 1, 1987·Circulation Research·G ZuanettiP J Schwartz
Jan 1, 1990·Annals of the New York Academy of Sciences·G M De Ferrari, P J Schwartz
Feb 26, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Vivek GargAlexey Zaitsev

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