Efficacy of entecavir treatment among chronic hepatitis B nucleos(t)ide-naïve and -experienced patients

Turkish Journal of Medical Sciences
Kadir Çağatay BiçerFatma Bal

Abstract

To evaluate the efficacy of entecavir (ETV) among chronic hepatitis B (CHB) nucleos(t)ide-naive and -experienced patients in clinical practice. In this retrospective study 85 CHB patients who had been receiving ETV and who attended our clinic since 2007 were included. Fifty patients were nucleos(t)ide analogue (NA)-naïve. Factors including sex, positive HBeAg, baseline HBV DNA level, baseline alanine aminotransferase level, and prior lamivudine (LAM) resistance were evaluated in terms of their predictive role in treatment response, which was defined as a serum HBV DNA decrease of <31.4 copies/mL. Resistance was detected in 18 (51.4%) of 35 lamivudine-experienced patients. Virological response (VR) was achieved in 48 (96.0%) of NA-naive patients, while 16 (45.7%) of NA-experienced patients achieved VR. LAM-resistant patients had significantly lower response rates (P < 0.001). More responders with a low initial viral load achieved VR at the end of the 12-month follow-up period compared to those with a high initial viral load (91.7% vs. 70.0%, P = 0.004). ETV has greater efficacy in NA-naïve patients and in NA-experienced patients without prior LAM resistance. The rate of VR achievement at 12 months was higher in patients who init...Continue Reading

Citations

May 25, 2016·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Gautam Ray
Oct 1, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kuo-Chih TsengJia-Horng Kao

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