Efficacy of enzymatic mouth rinses for immobilisation of protective enzymes in the in situ pellicle

Archives of Oral Biology
Christian HannigMatthias Hannig

Abstract

Mouth rinses containing enzymes are designed for patients suffering from xerostomia. The objective of the present in situ study was to investigate the efficacy of these rinses for targeted accumulation and immobilisation of protective enzymes in the acquired pellicle. A number of six healthy subjects carried bovine enamel slabs fixed on individual upper jaw splints for pellicle formation in situ. After 1 min, they rinsed with biotène or BioXtra for 10 min, respectively. Enzyme activities of lysozyme, peroxidase and glucoseoxidase in the in situ pellicle and in the saliva were assayed before as well as 0, 20 and 40 min after the rinses. The assays for the respective enzyme activities were based on fluorogenic substrates. Separate experiments were performed for the different enzymes and mouth rinses, respectively. Statistical evaluation was carried out with the Kruskal-Wallis test. None of the investigated rinses had any significant impact on the activities of lysozyme, peroxidase and glucoseoxidase detectable in the in situ pellicle or in the saliva (Kruskal-Wallis test, p>0.05). Despite the fact that both products should contain lactoperoxidase activity according to manufacturers' instructions, no peroxidase activity was measur...Continue Reading

References

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Feb 8, 2005·European Journal of Oral Sciences·Christian HannigThomas Attin
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Jan 22, 2008·Archives of Oral Biology·C HannigM Hannig
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Apr 22, 2008·Archives of Oral Biology·Christian HannigMatthias Hannig
May 13, 2008·Journal of Dentistry·Christian HannigMatthias Hannig
Sep 24, 2008·Clinical Oral Investigations·Christian HannigMatthias Hannig
Apr 28, 2009·Journal of Dentistry·Christian HannigAli Al-Ahmad

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Citations

May 4, 2012·Clinical Oral Investigations·Christian HannigKlaus Kümmerer
Dec 5, 2012·Caries Research·D H J JagerM C D N J M Huysmans
Jan 9, 2013·International Journal of Molecular Sciences·Jason N ZimmermanWalter L Siqueira
Jan 3, 2013·Biotechnology Journal·Barbara ThallingerGeorg M Guebitz
Sep 1, 2015·European Journal of Oral Sciences·Susann GrychtolChristian Hannig
Jun 7, 2015·International Journal of Biological Macromolecules·Małgorzata PleszczyńskaJanusz Szczodrak
Dec 6, 2011·Archives of Oral Biology·Hong-Seop KhoSang-Goo Lee
Sep 29, 2012·Journal of Dental Research·W L SiqueiraE E McDonald
May 5, 2016·The Journal of Social Psychology·Elizabeth M KiebelJulie C Herbstrith
Oct 3, 2018·BDJ Open·Siân B JonesSvetlana A Zakirova

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