Efficacy of epidural administration of anti-interleukin-6 receptor antibody onto spinal nerve for treatment of sciatica.

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Seiji OhtoriKazuhisa Takahashi

Abstract

Interleukin-6 (IL-6) is thought to play a crucial role in the radicular pain caused by lumbar spinal stenosis. However, efficacy of inhibition of IL-6 for sciatica in patients with lumbar spinal stenosis has not been clarified. The purpose of the current study was to examine the effect of the anti-IL-6 receptor monoclonal antibody, tocilizumab, on radicular pain by its epidural administration onto spinal nerves in patients with lumbar spinal stenosis. Sixty patients with low back and radicular leg pain caused by spinal stenosis were investigated. In 30 patients, we infiltrated 2.0 mL of lidocaine and 80 mg of tocilizumab onto the affected spinal nerve, and 2.0 mL of lidocaine and 3.3 mg of dexamethasone were used in 30 patients. Low back pain, leg pain, and leg numbness were evaluated during 1 month after spinal nerve infiltration. Infiltration of tocilizumab was more effective than dexamethasone for leg pain (3 days, 1, 2, and 4 weeks), low back pain (3 days, 1, 2 and 4 weeks), and leg numbness (3 days, 1 and 2 weeks). No adverse event was observed in either group. Our results indicate that the epidural administration of an anti-IL-6 receptor monoclonal antibody, tocilizumab, onto the spinal nerve produced reduction of radicul...Continue Reading

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Citations

Jan 10, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Michel Benoist
Dec 18, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Michel Benoist
Oct 30, 2013·Nature Reviews. Rheumatology·Makarand V Risbud, Irving M Shapiro
Apr 20, 2013·Regional Anesthesia and Pain Medicine·Honorio T Benzon
Nov 9, 2012·International Journal of Biological Sciences·Toshio Tanaka, Tadamitsu Kishimoto
Apr 15, 2014·Drug Design, Development and Therapy·Anjali ShettyNadera J Sweiss
May 27, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Takeshi SainohSeiji Ohtori
Feb 5, 2015·ANZ Journal of Surgery·Thomas J Fisher, Orso L Osti
Sep 6, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wei YangWen-Jun Wang
Jun 15, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Masashi SatoSeiji Ohtori
Aug 12, 2014·Behavioural Neurology·Ersoy KocabicakOmer Iyigun
Jul 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Wei-Chun LinKathryn M Albers
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May 8, 2020·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Qing-Qing YangXiao-Yan Zeng
Dec 6, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Aleksandra SadowskaOliver N Hausmann
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Mar 6, 2015·ACS Applied Materials & Interfaces·Khosrow KhodabandehlouJoseph M DeSimone

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