PMID: 11328297May 1, 2001Paper

Efficacy of epoetin alfa in the treatment of anaemia of multiple myeloma

British Journal of Haematology
Franco DammaccoS Rödjer

Abstract

Effects of epoetin alfa on transfusions, haemoglobin (Hb) and quality of life (QOL) were evaluated in a placebo-controlled study of 145 patients with multiple myeloma and anaemia (Hb < 11 g/dl). During the 12-week, double-blind phase, patients received 150 IU/kg epoetin alfa or a matching volume of placebo subcutaneously three times weekly; the dose (or volume) was doubled at week 4 if Hb response was inadequate. Patients completing this phase could enter the subsequent optional 12-week phase of open-label epoetin alfa treatment. During double-blind treatment, epoetin alfa significantly decreased the incidence of transfusion compared with placebo (28% vs. 47%, P = 0.017), regardless of patients' transfusion history, and increased mean Hb (1.8 g/dl vs. 0.0 g/dl, P < 0.001). Univariate analysis showed significant (P </= 0.05) improvement in more QOL measures with epoetin alfa than with placebo; multivariate analysis discerned no between-treatment differences. Significantly (P = 0.038) more epoetin alfa vs. placebo patients had improved performance scores. At the end of the open-label treatment phase, patients who had continued epoetin alfa maintained Hb status, and placebo patients who were switched to epoetin alfa had mean Hb in...Continue Reading

References

Jan 1, 1975·Archives of Internal Medicine·Z JancelewiczW Pruzanski
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A RiccardiE Ascari
Jun 14, 1990·The New England Journal of Medicine·H LudwigU Barnas
Jan 1, 1989·Social Science & Medicine·R A Carr-Hill, P Kind
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Abels
Feb 1, 1993·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H LudwigH Umek
Aug 1, 1995·Leukemia & Lymphoma·Y Beguin
Dec 1, 1995·Psychological Reports·D L StronksF Heule
Jan 1, 1996·Seminars in Surgical Oncology·S Shousha
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J GlaspyS Vadhan-Raj
Apr 16, 1998·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·M R Visser, E M Smets
Aug 5, 1998·International Journal of Clinical & Laboratory Research·F DammaccoL Resegotti
Feb 11, 1999·The New England Journal of Medicine·L T GoodnoughJ P AuBuchon
Feb 19, 1999·Lancet·G Gahrton

❮ Previous
Next ❯

Citations

Aug 4, 2005·Annals of Hematology·Michael Heuser, Arnold Ganser
Jul 17, 2008·Annals of Hematology·Nadine ShehataUNKNOWN Cancer Care Ontario Hematology Disease Site Group
Oct 14, 2004·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Massimo MartinoFortunato Morabito
Apr 30, 2003·Current Treatment Options in Oncology·Jesús F San Miguel, Ramón García-Sanz
Nov 18, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Vicente Alberola CandelUNKNOWN Spanish Society of Medical Oncology
Jun 15, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J H SavonijeG Giaccone
Oct 18, 2002·European Journal of Internal Medicine·Marie Chowrimootoo, David Oliveira
Sep 6, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D KotasekUNKNOWN Aranesp 980291 Study Group
Jun 20, 2003·Joint, Bone, Spine : Revue Du Rhumatisme·Didier ClercXavier Mariette
May 7, 2003·The Lancet Oncology·Ambuj KumarBenjamin Djulbegovic
Sep 12, 2007·Bone Marrow Transplantation·T J Littlewood, G P Collins
Dec 12, 2001·British Journal of Haematology·UNKNOWN UK myeloma forum. British Committee for Standards in Haematology
Oct 3, 2002·British Journal of Haematology·Michael HedenusUNKNOWN Darbepoetin alfa 990114 Study Group
Mar 6, 2003·Reviews in Clinical and Experimental Hematology·Jean-Luc Harousseau
Nov 26, 2002·Seminars in Hematology·David J Straus
Apr 7, 2005·Journal of the National Cancer Institute·Julia BohliusAndreas Engert
May 18, 2006·Journal of the National Cancer Institute·Julia BohliusAndreas Engert
May 2, 2002·Anti-cancer Drugs·S Zweegman, P C Huijgens
May 2, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Marcello TonelliScott Klarenbach
Sep 28, 2007·Drugs & Aging·Hang QuachLinda Mileshkin
Aug 21, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sheng GaoCheng Lu
Sep 19, 2003·Wiener klinische Wochenschrift·Heinz Gisslinger, Mathias Kees
Oct 29, 2002·Leukemia & Lymphoma·Marco TucciFranco Dammacco
Nov 11, 2003·Current Medical Research and Opinion·Nick Bosanquet, Keith Tolley
Jun 10, 2009·Current Medical Research and Opinion·Valentina TzekovaUNKNOWN Epoetin Zeta Oncology Study Group
Aug 31, 2002·Medical and Pediatric Oncology·P A Voûte
Aug 31, 2002·Medical and Pediatric Oncology·P A Voûte
Mar 8, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Daniel Limi CacicJerard Seghatchian
Jan 25, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·David S Cheng, Michael W O'Dell
Apr 25, 2009·Seminars in Hematology·Evangelos TerposHeinz Ludwig
Mar 4, 2009·Current Problems in Cancer·S Vincent Rajkumar
Oct 15, 2003·Clinical Lymphoma·Moshe Mittelman
Aug 2, 2006·Clinical Lymphoma & Myeloma·Asher Chanan-Khan, Kena C Miller
Dec 12, 2007·Best Practice & Research. Clinical Haematology·Heinz Ludwig, Niklas Zojer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.