PMID: 15233455Jul 6, 2004Paper

Efficacy of eprinomectin pour-on against gastrointestinal nematodes and the nasal bot fly (Oestrus ovis) in sheep

The Veterinary Record
H HosteP Dorchies

Abstract

The efficacy of the pour-on formulation of eprinomectin, at a dose rate of 0.5 mg/kg bodyweight, was assessed in sheep against three main species of gastrointestinal nematodes and against the nasal bot fly, Oestrus ovis, and some pharmacokinetic parameters were determined for 21 days after the treatment. By comparison with untreated control sheep, infected experimentally with Haemonchus contortus, Teladorsagia circumcincta and Trichostrongylus colubriformis, eprinomectin was 100 per cent effective against the two abomasal species and 99.5 per cent effective against T. colubriformis. In ewes naturally infected with the nasal bot fly, the efficacy of the drug against O. ovis was 97.7 per cent. The mean (se) systemic area under the curve (AUC) was 56.0 (26.2) ng/day/ml and the mean residence time was 5.3 (1.0) days, but there were wide variations between individual sheep.

References

Mar 1, 1982·Journal of Pharmaceutical Sciences·D Perrier, M Mayersohn
Nov 1, 1996·International Journal for Parasitology·W L ShoopM J Turner
Dec 22, 1999·Veterinary Research Communications·M AlvinerieC Chartier
May 18, 2001·Parasitology Research·J DupuyM Alvinerie
Dec 4, 2001·International Journal for Parasitology·C M LaffontP L Toutain
Dec 19, 2002·Parasitology Research·A LespineM Alvinerie
Feb 20, 2003·Veterinary Parasitology·G CringoliG Capelli
Feb 1, 1997·New Zealand Veterinary Journal·R P GogolewskiJ S Eagleson

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Citations

Oct 31, 2008·Australian Veterinary Journal·J M MolinaY I Hernández
Jun 9, 2006·Veterinary Parasitology·Donato Traversa, Domenico Otranto

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