Efficacy of equilibrium radionuclide angiography to predict acute response to cardiac resynchronization therapy in patients with heart failure

Nuclear Medicine Communications
Yu ChenLiansheng Wang

Abstract

To predict the acute response to cardiac resynchronization therapy (CRT) in patients with left ventricular mechanical dyssynchrony using equilibrium radionuclide angiography (ERNA). A total of 24 consecutive heart failure patients scheduled for CRT were included. ERNA was performed before and within 48 h after pacemaker implantation to calculate both left ventricular (LV) volumes and LV dyssynchrony. LV dyssynchrony was defined as the standard left ventricular phase shift and left ventricular phase standard deviation (LVPS% and LVPSD%). Patients were subsequently divided into acute responders or nonresponders, based on a reduction of at least 15% in LV end-systolic volume immediately after CRT. Fifteen patients (63%) were classified as acute responders. Baseline characteristics were similar between responders and nonresponders except for the LVPS% and LVPSD%, which were larger in responders. Moreover, responders demonstrated a significant reduction of LVPS% and LVPSD% immediately after CRT (from 28.00±2.88 to 17.53±4.94 and 11.20±2.54 to 5.60±1.80, P<0.001), whereas in nonresponders LVPS% and LVPSD% remained unchanged (from 21.44±3.91 to 19.56±4.22% and 6.55±1.51 to 6.22±1.30%, P=NS). Receiver operating characteristic curve ana...Continue Reading

References

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Citations

Oct 28, 2016·Annals of Nuclear Medicine·Olivier Lairez, Denis Agostini
Mar 30, 2017·Computational and Mathematical Methods in Medicine·Alejandro Santos-DíazLuis Jiménez-Ángeles

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

SPSS16
Xeleris
GE XT - ERNA
ERNA
RT3DE
XT

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