PMID: 11334066May 4, 2001Paper

Efficacy of erythromycin for postpyloric placement of feeding tubes in critically ill children: a randomized, double-blind, placebo controlled study

JPEN. Journal of Parenteral and Enteral Nutrition
V GharpureA P Sarnaik

Abstract

Erythromycin enhances gastric emptying and has been suggested to facilitate nasoenteric feeding tube placement in adults. Our primary objective was to evaluate the effect of erythromycin on the transpyloric passage of feeding tubes in critically ill children, and second, to evaluate the effect of erythromycin on the distal migration of duodenal feeding tubes. Seventy-four children were randomly assigned to receive erythromycin lactobionate (10 mg/kg) IV or equal volume of saline placebo 60 minutes before passage of a flexible weighted tip feeding tube. Abdominal radiographs were obtained 4 hours later to assess tube placement. If the tube was proximal to the third part of the duodenum, two additional doses of erythromycin/placebo were administered 6 hours apart. Those receiving additional doses had repeat radiographs 14 to 18 hours after tube placement. The number of postpyloric feeding tubes was similar in the erythromycin and placebo treated groups 4 hours after tube insertion (23/37 vs 27/37, p = .5). Of those with prepyloric tubes at 4 hours, none in the erythromycin group and 3 in the placebo group had the tube migrate to the postpyloric position by 14 to 18 hours (p < .05). Of those with postpyloric tubes proximal to the ...Continue Reading

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Citations

Apr 13, 2006·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Marsha L Cirgin Ellett
Mar 19, 2009·World Journal of Gastroenterology : WJG·Eva NivNachum Vaisman
May 12, 2004·Heart & Lung : the Journal of Critical Care·Norma A MethenySharon J Edwards
Oct 15, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·Lorri M PhippsNeal J Thomas
Aug 26, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Huang TianchaYan Min
Jul 28, 2015·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Carolina PuiggròsRosa Burgos
Nov 20, 2012·Nutrition and Health·Dória M LeãesMichelli Cristina de Silva Assis
Apr 13, 2004·Current Opinion in Critical Care·Andrew R Davies, Rinaldo Bellomo
Mar 31, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Sven van den BoschAdriaan C I T L Tan
Feb 1, 2018·Pediatric Gastroenterology, Hepatology & Nutrition·Dae Yong Yi
May 11, 2010·Journal of Pediatric Gastroenterology and Nutrition·Christian BraeggerJohannes van Goudoever
Jan 19, 2019·The Cochrane Database of Systematic Reviews·Malene Plejdrup HansenChris B Del Mar
Mar 7, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kathleen L Meert, Norma Metheny
Jun 1, 2018·Gastroenterology Research and Practice·Qing-Jun JiangBin Shi
Jan 25, 2003·Critical Care Medicine·Craig K Hallstrom, Brian R Jacobs
Aug 18, 2018·European Journal of Pediatrics·Lyvonne N Tume, Frédéric V Valla
Feb 6, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Kunal R GadhviLyvonne N Tume

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