Efficacy of essential oils from plants cultivated in the Amazonian Biome against gastrointestinal nematodes in sheep

Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology
Ana Carolina S ChagasFrancisco C M Chaves

Abstract

The excessive use of anthelmintics to control nematodes has resulted in anthelminthic resistance. Essential oils (EOs) are a rich source of bioactive molecules that can be assessed for their ability to control resistant parasite populations. The aims of this study were to screen EOs from 10 plant species in vitro for anthelmintic activity against Haemonchus contortus, evaluate the cytotoxicity of those EOs in a human immortalized keratinocyte cell line (HaCaT), and test the most promising EO candidate in vivo in Santa Inês sheep. The efficacy was investigated in vitro using an egg hatch test (EHT) and a larval development test (LDT). EO cytotoxicity was evaluated with the sulforhodamine-B assay. In the in vivo experiment, 28 Santa Inês sheep naturally infected were distributed into groups: G1-Mentha arvensis (EO5), 200 mg kg-1; G2-menthol, 160 mg kg-1; G3-negative control; and G4-positive control (monepantel). EO5, from M. arvensis (86.7% menthol), had the lowest LC50 and LC90 values in the EHT (0.10, 0.27 mg mL-1, respectively), good performance in the LDT (0.015, 0.072 mg mL-1, respectively), and the lowest cytotoxicity (190.9 µg mL-1) in HaCaT cells. In the in vivo test, a single dose of the EO5 (200 mg kg-1 BW) had an effic...Continue Reading

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Feb 13, 2016·Ticks and Tick-borne Diseases·Ana Carolina de Souza ChagasFrancisco Celio Maia Chaves

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Citations

Jan 15, 2021·Comprehensive Reviews in Food Science and Food Safety·Jonas Joaquim Mangabeira da SilvaJonas Augusto Rizzato Paschoal

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Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

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