Efficacy of etoricoxib, celecoxib, lumiracoxib, non-selective NSAIDs, and acetaminophen in osteoarthritis: a mixed treatment comparison.

The Open Rheumatology Journal
Wb StamSd Taylor

Abstract

To compare the efficacy of etoricoxib, lumiracoxib, celecoxib, non-selective (ns) NSAIDs and acetaminophen in the treatment of osteoarthritis (OA) METHODS: Randomized placebo controlled trials investigating the effects of acetaminophen 4000mg, diclofenac 150mg, naproxen 1000mg, ibuprofen 2400mg, celecoxib 100-400mg, lumiracoxib 100-400mg, and etoricoxib 30-60mg with treatment duration of at least two weeks were identified with a systematic literature search. The endpoints of interest were pain, physical function and patient global assessment of disease status (PGADS). Pain and physical function reported on different scales (VAS or LIKERT) were translated into effect sizes (ES). An ES 0.2 - 0.5 was defined as a "small" treatment effect, whereas ES of 0.5 - 0.8 and > 0.8 were defined as "moderate" and "large", respectively. A negative effect indicated superior effects of the treatment group compared to the control group. Results of all trials were analyzed simultaneously with a Bayesian mixed treatment comparison. There is a >95% probability that etoricoxib (30 or 60mg) shows the greatest improvement in pain and physical function of all interventions compared. ESs of etoricoxib 30mg relative to placebo, celecoxib 200mg, ibuprofe...Continue Reading

Citations

May 30, 2013·Wiener medizinische Wochenschrift·Klaus Bobacz
May 23, 2017·The Cochrane Database of Systematic Reviews·Livia PuljakPeter Tugwell
Apr 16, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Cindy CrawfordUNKNOWN HERB Working Group
Apr 16, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Courtney BoydUNKNOWN HERB Working Group
Jan 13, 2015·International Journal of Immunopathology and Pharmacology·G BianchiR Saggini
Feb 1, 2017·Terapevticheskiĭ arkhiv·B V ZavodovskyI A Zborovskaya
Aug 20, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·UNKNOWN Redaktsiia

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