Efficacy of fixed-dose combination therapy in the treatment of patients with hypertension: focus on amlodipine/valsartan.

Clinical Drug Investigation
Pedro Marques da Silva

Abstract

Early initiation of rational and effective combination therapy consisting of antihypertensive drugs with two different and complementary mechanisms of actions is increasingly becoming accepted in clinical practice and by guidelines as a first-line approach to control blood pressure (BP) and prevent cardiovascular outcomes in patients with hypertension. Once-daily combination therapy provides more rapid control of BP, which is important for preventing cardiovascular events, with similar or improved tolerability compared with the component monotherapies, and improved adherence because of regimen simplification. Combination therapy with a calcium channel antagonist (calcium channel blocker [CCB]) and an inhibitor of the renin-angiotensin-aldosterone system (RAAS) is a rational approach to achieve BP goals and provide protection against renal and cardiovascular morbidity and mortality. A number of CCB/RAAS inhibitor combinations, including CCB/angiotensin-converting enzyme (ACE) inhibitor and CCB/ angiotensin II type 1 receptor antagonist (angiotensin receptor blocker [ARB]) combinations are available as fixed-dose formulations. There is substantial evidence for the BP-lowering efficacy of CCB/RAAS inhibitor combinations in diverse...Continue Reading

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Citations

Jun 28, 2013·Journal of Human Hypertension·J R M'Buyamba-KabanguUNKNOWN Newer versus Older Antihypertensive Agents in African Hypertensive Patients Trial (NOAAH) Investigators
Nov 1, 2013·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Hee Youn ChoiHyeong-Seok Lim
Jul 25, 2014·Clinical Medicine Insights. Cardiology·Olugbenga O AbiodunAnthony O Akintomide

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