Efficacy of fleroxacin in experimental methicillin-resistant Staphylococcus aureus endocarditis.

Antimicrobial Agents and Chemotherapy
G W KaatzM J Rybak

Abstract

The efficacy of fleroxacin versus that of vancomycin was assessed by using the rabbit model of methicillin-resistant Staphylococcus aureus endocarditis. Animals were treated with fleroxacin (30 mg/kg of body weight every 8 h) or vancomycin (17.5 mg/kg every 6 h) for 4 days. These antimicrobial agents were equally effective in clearing bacteremia, reducing bacterial counts in vegetations and tissues, and curing endocarditis. However, resistance to fleroxacin at fivefold the MIC arose in the test strain of S. aureus in 8% of animals that received the drug. We conclude that fleroxacin is as efficacious as vancomycin in this model of a serious systemic S. aureus infection, but modest resistance to fleroxacin may develop during therapy.

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Citations

Apr 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·W M Scheld
Jul 1, 1994·International Journal of Antimicrobial Agents·R H RubinA J Fischman
Feb 1, 1997·Journal of Ethnopharmacology·A Hiermann, F Bucar
Feb 1, 1990·Antimicrobial Agents and Chemotherapy·G W KaatzM J Rybak
Oct 1, 1993·Antimicrobial Agents and Chemotherapy·A J FischmanH W Strauss
Jun 13, 1998·Antimicrobial Agents and Chemotherapy·M W ClimoG L Archer
Apr 4, 1998·Antimicrobial Agents and Chemotherapy·G W KaatzM J Rybak

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