Efficacy of frog skin lipids in wound healing.

Lipids in Health and Disease
Venkat Raghavan KKorrapati Purna Sai

Abstract

Frog skin has been sequentially and scientifically evaluated by our group for its wound healing efficiency. Owing to the complex structure of skin, attempts were being made to analyse the role of individual constituents in different phases of healing. Our earlier papers have shown the significance of frog skin not only in wound healing but also enhancing the proliferating activity of the epidermal and dermal cells which are instrumental for normal healing process. We also have identified for the first time novel antimicrobial peptides from the skin of Rana tigerina and thereby reduce the complications involved in the sepsis. The current study envisages the role of frog skin lipids in the inflammatory phase of wound healing. The lipid moiety of the frog skin dominated by phospholipids exhibited a dose dependent acceleration of healing irrespective of the mode of application. The efficiency of the extract is attributed partially to the anti-inflammatory activity as observed by the histochemical and immunostimulatory together with plethysmographic studies. Thus, frog skin for the first time has been demonstrated to possess lipid components with pharmaceutical and therapeutic potential. The identification and characterization of su...Continue Reading

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Citations

Jan 21, 2014·The International Journal of Biochemistry & Cell Biology·Han LiuRen Lai
Jan 8, 2016·Experimental Dermatology·Maria Luisa MangoniMichael Zasloff
Aug 15, 2014·The FEBS Journal·Han LiuRen Lai
Dec 5, 2013·Biological Reviews of the Cambridge Philosophical Society·Iain S HaslamRalf Paus
Oct 16, 2015·Jundishapur Journal of Microbiology·Mahere Rezazade BazazMorteza Behnam Rassouli
Sep 21, 2013·Pharmaceutical Biology·Mahere Rezazade BazazShiva Golmohammadzadeh
Oct 5, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·X J ChenW S Jiang
Jan 1, 2019·International Journal of Peptide Research and Therapeutics·Fatemeh ZohrabReza Kazemi Oskuee

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