Efficacy of frovatriptan versus other triptans in the acute treatment of menstrual migraine: pooled analysis of three double-blind, randomized, crossover, multicenter studies

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
G AllaisG Bussone

Abstract

The objective of this study was to review the efficacy and safety of frovatriptan (F) versus rizatriptan (R), zolmitriptan (Z) and almotriptan (A), in women with menstrually related migraine (IHS criteria) through a pooled analysis of three individual studies. Subjects with a history of migraine with or without aura were randomized to F 2.5 mg or R 10 mg (study 1), F or Z 2.5 mg (study 2), and F or A 12.5 mg (study 3). The studies had an identical multicenter, randomized, double-blind, crossover design. After treating three episodes of migraine in no more than 3 months with the first treatment, patients had to switch to the next treatment for other 3 months. 346 subjects formed intention-to-treat population of the main study; 280 of them were of a female gender, 256 had regular menses and 187 were included in the menstrual migraine subgroup analysis. Rate of pain free at 2, 4 and 24 h was 23, 52 and 67 % with F and 30, 61 and 66 % with comparators (P = NS). Pain relief episodes at 2, 4 and 24 h were 37, 60 and 66 % for F and 43, 55 and 61 % for comparators (P = NS). Rate of recurrence was significantly (P < 0.05) lower under F either at 24 h (11 vs. 24 % comparators) or at 48 h (15 vs. 26 % comparators). Number of menstrual mig...Continue Reading

References

Feb 17, 2001·Current Treatment Options in Neurology·Elizabeth Loder
Jan 21, 2004·Current Pain and Headache Reports·Morris Levin
Apr 29, 2004·Health Reports·H Gilmour, K Wilkins
Nov 5, 2005·CNS Drugs·Lisa K Mannix, Julia A Files
Dec 13, 2005·Journal of Clinical Pharmacy and Therapeutics·N PoolsupM Khanthong
May 12, 2006·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G AllaisG Bussone
Nov 16, 2007·Expert Opinion on Pharmacotherapy·Färkkilä Markus, Kallela Mikko
Dec 23, 2008·Headache·Vincent T Martin, Richard B Lipton
Jan 8, 2009·Current Pain and Headache Reports·Frederick R Taylor
Jul 2, 2010·The New England Journal of Medicine·Elizabeth Loder
Jul 21, 2010·Current Medical Research and Opinion·Leslie KelmanJohn C Campbell
Sep 15, 2010·Drugs·E Anne MacGregor
May 6, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Gianni AllaisGennaro Bussone
Jun 19, 2013·Cephalalgia : an International Journal of Headache·UNKNOWN Headache Classification Committee of the International Headache Society (IHS)

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Citations

May 25, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Gianni AllaisChiara Benedetto
May 25, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G AllaisG Bussone
Mar 14, 2013·Therapeutic Advances in Neurological Disorders·Gianni Allais, Chiara Benedetto
May 29, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Cinzia Finocchi, Laura Strada
May 29, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Flavia FranconiGennaro Bussone
Dec 10, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alessandro Della PuppaLuca Persano
Jan 29, 2017·Expert Opinion on Pharmacotherapy·Amanda E Macone, Michael D Perloff
Dec 8, 2017·Expert Opinion on Pharmacotherapy·G AllaisChiara Benedetto
Nov 20, 2020·Neurology·Daphne S van CasterenAntoinette MaassenVanDenBrink
Jun 3, 2021·Journal of Clinical Medicine·Raffaele OrnelloSimona Sacco

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