Efficacy of Gabapentin for the Treatment of Alcohol Use Disorder in Patients With Alcohol Withdrawal Symptoms: A Randomized Clinical Trial.

JAMA Internal Medicine
Raymond F AntonEmily Bristol

Abstract

Although an estimated 30 million people meet criteria for alcohol use disorder (AUD), few receive appropriate pharmacotherapy. A more personalized, symptom-specific, approach might improve efficacy and acceptance. To examine whether gabapentin would be useful in the treatment of AUD, especially in those with the most alcohol withdrawal symptoms. This double-blind randomized clinical trial conducted between November 2014 and June 2018 evaluated gabapentin vs placebo in community-recruited participants screened and treated in an academic outpatient setting over a 16-week treatment period. A total of 145 treatment-seeking individuals who met Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) criteria for AUD and were not receiving other AUD intervention were screened, and 96 who also met recent alcohol withdrawal criteria were randomized to treatment after 3 abstinent days. Daily drinking was recorded, and percentage of disialo carbohydrate-deficient transferrin in the blood, a heavy drinking marker, was collected at baseline and monthly during treatment. Gabapentin up to 1200 mg/d, orally, vs placebo along with 9 medical management visits (20 minutes each). The percentage of individuals with no heavy drinking d...Continue Reading

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Citations

Jul 7, 2020·Alcoholism, Clinical and Experimental Research·Christopher T RentschJanet P Tate
Jul 18, 2020·JAMA Internal Medicine·Robert A Kleinman, Michael J Ostacher
Sep 10, 2020·International Journal of Molecular Sciences·Shao-Cheng WangChing-Ming Cheng
Jul 18, 2020·JAMA Internal Medicine·Raymond F Anton, Michaela Hoffman
Nov 20, 2020·The American Journal of Psychiatry·Rajita SinhaHelen C Fox
Jan 22, 2021·The American Journal of Emergency Medicine·Sally MahmoudAndrew A Herring
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Jun 8, 2021·The American Journal of Drug and Alcohol Abuse·John J MarianiFrances R Levin
Jun 3, 2021·International Journal of Molecular Sciences·Szu-Yi LiuYin-Chou Hsu
May 18, 2021·Frontiers in Psychiatry·Francina FonsecaMarta Torrens
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Sep 24, 2021·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Jing LiQiaozhen Xi
Nov 3, 2021·Nature Reviews. Gastroenterology & Hepatology·Juan Pablo ArabVijay H Shah

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