Efficacy of gabapentin in the treatment of SUNCT syndrome

Cephalalgia : an International Journal of Headache
M EtemadifarM Kaji Esfahani

Abstract

This study was designed to evaluate the efficacy of gabapentin (GBP) in the treatment of SUNCT syndrome on a relatively large sample of Persian patients. Eight patients with SUNCT syndrome underwent a 4-week, open-label, daily treatment of 600-900 mg GBP. The frequency, intensity and duration of attacks were compared before and after the trial. After 4 weeks of treatment, intensity, duration and frequency of headaches were significantly (P < 0.05) reduced. In addition, five patients (62.5%) were completely relieved from headaches, and in the other three patients the mean intensity, frequency and duration of headaches were decreased notably. In this study, GBP was well tolerated and no unfavourable side-effects were reported. After the end of the trial all patients continued the medication, and after 3 months none reported undesired side-effects or return of the headaches to the pre-treatment status. Our patients had a significant response to GBP, and considering other case reports on the effectiveness of GBP in the treatment of SUNCT syndrome, we propose that, taking into account the good side-effect profile and lack of interactions of GBP, this drug could be considered as an option for the treatment of SUNCT.

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Citations

Apr 30, 2010·The Journal of Headache and Pain·Anna Kutschenko, David Liebetanz
Dec 18, 2012·Current Treatment Options in Neurology·Juan A ParejaTeresa Montojo
Jul 21, 2009·Cephalalgia : an International Journal of Headache·P IrimiaE Martínez-Vila
May 21, 2011·Rinshō shinkeigaku = Clinical neurology·Yasuhiro ItoTakeshi Yasuda
Jun 27, 2013·Cephalalgia : an International Journal of Headache·Valentina FavoniSabina Cevoli
Oct 11, 2015·Cephalalgia : an International Journal of Headache·Arne May, Peter Goadsby
Dec 1, 2012·Cephalalgia : an International Journal of Headache·Prin Chitsantikul, Werner J Becker
Nov 3, 2010·Cephalalgia : an International Journal of Headache·Masako IkawaShinya Manaka
Jun 30, 2014·Current Pain and Headache Reports·Sarah Miller, Manjit Matharu
Oct 5, 2013·Headache·Juan A Pareja, Mónica Álvarez
Jun 21, 2015·Current Pain and Headache Reports·Jared L Pomeroy, Stephanie J Nahas
Sep 24, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Michael D PerloffDonna Kurowski
Dec 29, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Giorgio LambruManjit Singh Matharu
May 19, 2021·Neurology India·Ashish K Duggal, Debashish Chowdhury

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