PMID: 11328789May 1, 2001Paper

Efficacy of gatifloxacin alone and in combination with cefepime against penicillin-resistant Streptococcus pneumoniae in a rabbit meningitis model and in vitro

The Journal of Antimicrobial Chemotherapy
M PerrigPhilippe Cottagnoud

Abstract

Gatifloxacin penetrated well into cerebrospinal fluid (CSF) (49 +/- 11%), measured by comparison of AUC(CSF)/AUC(serum), and showed good bactericidal activity (leading to a decrease of 0.75 +/- 0.17 log10 cfu/mL/h) in the treatment of experimental meningitis in rabbits caused by a penicillin-resistant pneumococcal strain (MIC 4 mg/L). It was significantly more effective than the standard regimen, ceftriaxone with vancomycin, which led to a decrease of 0.53 +/- 0.17 log10 cfu/mL/h. The addition of cefepime to gatifloxacin slightly improved the killing rates (giving a decrease of 0.84 +/- 0.14 log10 cfu/mL/h). In vitro, synergy was demonstrated between cefepime and gatifloxacin by the chequerboard method (fractional inhibitory concentration index = 0.5) and by viable counts over 8 h.

References

May 1, 1994·Antimicrobial Agents and Chemotherapy·R NauM G Täuber
Oct 10, 1998·Clinical Microbiology Reviews·S L Kaplan, E O Mason
Jun 26, 1999·The Journal of Antimicrobial Chemotherapy·D B HoellmanP C Appelbaum
Dec 22, 1999·Emerging Infectious Diseases·G V DoernE Wingert
Aug 10, 2000·The Journal of Antimicrobial Chemotherapy·C M GerberP Cottagnoud
Apr 22, 1960·Biochimica Et Biophysica Acta·S LACKS, R D HOTCHKISS

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Citations

Jul 18, 2003·Current Infectious Disease Reports·Philippe Cottagnoud, Martin G. Täuber
Apr 23, 2004·Expert Opinion on Investigational Drugs·P H Cottagnoud, M G Täuber
Nov 17, 2009·Infectious Disease Clinics of North America·Justine Miranda, Allan R Tunkel
Jan 21, 2006·Diagnostic Microbiology and Infectious Disease·Thomas P LodiseGeorge L Drusano
Aug 17, 2004·Infectious Disease Clinics of North America·Scott W Sinner, Allan R Tunkel
Nov 30, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Devyani DeshpandeTawanda Gumbo

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