Abstract
The objective of the present study was to evaluate the effectiveness of topically applied gemifloxacin for the treatment of experimental Staphylococcus aureus keratitis in a rabbit model. Rabbit corneas were intrastromally injected with ~100 colony-forming units (CFU) of S. aureus ATCC25923. Eight hours (early treatment) or 16 h (late treatment) after the injection, 1 topical drop of balanced salt solution (BSS), gemifloxacin ophthalmic solution (0.5%), levofloxacin ophthalmic solution (0.5%), or gatifloxacin eye gel (0.3%) was applied to each eye every 15 min for 5 doses and then, every 30 min for 14 doses. The eyes were examined both before and after treatment. The corneas were harvested from treated and untreated rabbits for the quantitation of bacteria and histological observation. In the early-treatment groups, all 3 fluoroquinolones significantly lowered the clinical severity of infection and the median erosion area of the cornea compared with the BSS control (P=0.000). In the late-treatment groups, gemifloxacin and levofloxacin did not cause a significant reduction in clinical scores compared with the BSS control (P=0.107 and 0.531, respectively), but the gatifloxacin caused a significant reduction in clinical scores com...Continue Reading
References
Sep 1, 1995·The Journal of Pharmacy and Pharmacology·H SasakiJ Nakamura
Jul 2, 2003·American Journal of Ophthalmology·Tulaya TungsiripatPeter J McDonnell
Jan 20, 2004·The Journal of Antimicrobial Chemotherapy·Ian Morrissey, Glenn Tillotson
May 25, 2004·Antimicrobial Agents and Chemotherapy·Joseph J DajcsRichard J O'Callaghan
Apr 30, 2005·American Journal of Ophthalmology·Eric G RomanowskiY Jerold Gordon
Feb 7, 2006·American Journal of Ophthalmology·Pragya ParmarChristdas Arul Nelson Jesudasan
Jul 31, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Eric G RomanowskiY Jerold Gordon
Sep 20, 2008·The Journal of Antimicrobial Chemotherapy·Steven N LeonardMichael J Rybak
Apr 28, 2009·Ophthalmology·Jae Lim ChungJin Kook Kim
Sep 3, 2009·Cornea·Melissa E SandersMary E Marquart
Oct 1, 2009·Clinical Ophthalmology·Joseph S Bertino
Mar 26, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Melissa E SandersMary E Marquart
Aug 28, 2010·The Journal of Pharmacy and Pharmacology·Xiang-gen WuHao-ran Jiang
Jan 29, 2011·Journal of Biomedicine & Biotechnology·Mary E Marquart
Mar 12, 2011·The Journal of Antimicrobial Chemotherapy·S M McHughH Humphreys
Jun 28, 2011·Journal of Cataract and Refractive Surgery·Renée SolomonTerry Kim
Nov 15, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Xianggen WuLingjuan Xu
Feb 15, 2012·Arquivos brasileiros de oftalmologia·Eduardo M Rocha
Citations
May 16, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Haoran JiangXianggen Wu
Oct 21, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Sertan GoktasAbdulkadir Bukus
Aug 25, 2016·International Journal of Antimicrobial Agents·Andreana MarinoGiuseppe Bisignano
Apr 3, 2020·Drug Development and Industrial Pharmacy·Guigang LiXianggen Wu
Oct 29, 2017·BMC Microbiology·Imke GrimmTanja Vollmer
Oct 21, 2020·Experimental Eye Research·Fan ZhangXianggen Wu
May 18, 2019·ACS Infectious Diseases·Venkatesh MayandiRajamani Lakshminarayanan