Efficacy of geraniin on dengue virus type-2 infected BALB/c mice

Virology Journal
Siti Aisyah Abdul AhmadSharifah S Hassan

Abstract

Dengue continues to be a major international public health concern. Despite that, there is no clinically approved antiviral for treatment of dengue virus (DENV) infections. In this study, geraniin extracted from the rind of Nephelium lappaceum was shown to inhibit the replication of DENV-2 in both in vitro and in vivo experiments. The effect of geraniin on DENV-2 RNA synthesis in infected Vero cells was tested using quantitative RT-PCR. The in vivo efficacy of geraniin in inhibiting DENV-2 infection was then tested using BALB/c mice with geraniin administered at three different times. The differences in spleen to body weight ratio, DENV-2 RNA load and liver damage between the three treatment groups as compared to DENV-2 infected mice without geraniin administration were determined on day eight post-infection. Quantitative RT-PCR confirmed the decrease in viral RNA synthesis of infected Vero cells when treated with geraniin. Geraniin seemed to provide a protective effect on infected BALB/c mice liver when given at 24 h pre- and 24 h post-infection as liver damage was observed to be very mild even though a significant reduction of DENV-2 RNA load in serum was not observed in these two treatment groups. However, when administered ...Continue Reading

References

Dec 23, 1999·The Journal of Infectious Diseases·D W VaughnA Nisalak
Mar 2, 2002·The Lancet Infectious Diseases·T P Monath
Jun 18, 2005·Virology·M V PaesO M Barth
Jan 1, 2008·Journal of Agricultural and Food Chemistry·Hideyuki ItoTsutomu Hatano
Jul 16, 2008·Antiviral Research·Lauren E Yauch, Sujan Shresta
Sep 2, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Marciano Viana PaesAda Maria de Barcelos Alves
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nont ThitilertdechaNuansri Rakariyatham
Jun 1, 2010·Memórias do Instituto Oswaldo Cruz·Raquel Elvira OcazionezElena Stashenko
Jun 23, 2010·International Journal of Biological Sciences·Mudiana MuhamadRohana Yusof
Aug 3, 2010·Experimental and Molecular Pathology·Rafael Freitas de Oliveira FrançaBenedito Antônio Lopes da Fonseca
Nov 17, 2010·Nature Reviews. Microbiology·Maria G GuzmanRosanna W Peeling
Jan 13, 2011·Angewandte Chemie·Stéphane QuideauLaurent Pouységu
Feb 11, 2011·Current Infectious Disease Reports·Annelies Wilder-SmithDuane J Gubler
Aug 4, 2011·Expert Review of Anti-infective Therapy·Stuart T PerrySujan Shresta
Feb 22, 2012·Bioorganic & Medicinal Chemistry Letters·Yajun YangJiangning Liu
Feb 23, 2012·Viruses·Simona Zompi, Eva Harris
Jul 12, 2012·The Journal of Infectious Diseases·Catherine A LaughlinAnthony S Fauci
Nov 13, 2012·BMC Complementary and Alternative Medicine·Keivan ZandiSazaly Abubakar
Jul 31, 2013·BMC Complementary and Alternative Medicine·Sau Har LeeShamala Devi Sekaran
Oct 1, 2013·Antiviral Research·Siew Pheng LimPei-Yong Shi
May 7, 2014·Journal of Pharmacology & Pharmacotherapeutics·Jissa Maria Cyriac, Emmanuel James
Feb 17, 2015·World Journal of Clinical Cases·Jayanta Samanta, Vishal Sharma
Feb 6, 2017·Scientific Reports·Sandra FrabasileJuliano Bordignon
Apr 12, 2017·Biochemical and Biophysical Research Communications·Hoda AayadiSaroj S Ghaskadbi

❮ Previous
Next ❯

Citations

Aug 6, 2020·Viruses·Gopinathan Pillai SreekanthThawornchai Limjindaporn
Dec 31, 2020·Biomolecules·Vanessa Loaiza-CanoDamião Pergentino de Sousa
Mar 24, 2021·Journal of Biochemical and Molecular Toxicology·Xiuhui WangZhe Wang
Feb 1, 2022·Expert Opinion on Drug Discovery·Alana B ByrneLaura B Talarico

❮ Previous
Next ❯

Datasets Mentioned

BETA
AJ556810.1

Methods Mentioned

BETA
PCR

Software Mentioned

GraphPad Prism

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.