PMID: 16538000Mar 16, 2006Paper

Efficacy of glimepiride on insulin resistance, adipocytokines, and atherosclerosis

The Journal of Medical Investigation : JMI
Kunihiko KoshibaSusumu Ito

Abstract

Plasma adiponectin levels increase after the administration of glimepiride. This unique effects would also be expected to improve other adipocytokines and have anti-atherosclerotic action in patients with metabolic syndrome. Thirty-four patients with type 2 diabetes mellitus who were administrated glibenclamide were randomly divided into two groups. In 20 patients glibenclamide was changed to glimepiride (GP group), and the administration of glibenclamide (GB group) was continued in 14 patients. Twelve patients receiving insulin therapy (INS group) were enrolled for comparison. The levels of plasma adiponectin, high sensitive-CRP, TNF-alpha, interleukin-6, homeostasis model assessment-insulin resistance (HOMA-IR), brachial-ankle pulse wave velocity (baPWV) and augmentation index (AI) were measured before and 28 weeks after the therapy. HOMA-IR in the GP group was significantly decreased compared to the GB group. Plasma adiponectin levels were significantly increased in the GP group but not in the other groups. TNF-alpha, interleukin-6 and high sensitive-CRP levels were significantly decreased in the GP group, but not in the other groups. The baPWV and AI levels did not change in either the GB or the INS group, but were signific...Continue Reading

References

Sep 1, 1974·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·T SagaS Hara
Oct 1, 1980·The American Journal of Cardiology·M O'Rourke
Aug 1, 1995·Diabetes Research and Clinical Practice·G MüllerK Geisen
Sep 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K E DraegerR Rosskamp
Apr 1, 1999·Journal of Hypertension·M F O'Rourke, G Mancia
Jul 10, 2003·Diabetes Research and Clinical Practice·Raimund WeitgasserAnton Klingler
Feb 8, 2005·Biochemical and Biophysical Research Communications·Kouichi InukaiShigehiro Katayama
Mar 15, 2005·The Journal of Biological Chemistry·Shuichi FukuenIichiro Shimomura
May 6, 2005·Treatments in Endocrinology·Jonathan Q Purnell, Christian Weyer
Jun 7, 2005·Diabetes Research and Clinical Practice·Kouichi InukaiShigehiro Katayama

❮ Previous
Next ❯

Citations

Sep 20, 2011·Diabetes, Obesity & Metabolism·A S AbdelmoneimS H Simpson
Jun 28, 2007·International Journal of Clinical Practice. Supplement·G Derosa
Sep 2, 2010·Cardiovascular Diabetology·L Romayne Kurukulasuriya, James R Sowers
Feb 18, 2014·Internal Medicine·Tatsuyori MoritaIchiro Shiojima
Jan 23, 2016·Journal of Diabetes and Its Complications·Jay J SalazarTimothy J Koh
Jul 21, 2009·Preventive Medicine·Toshiaki OtsukaYoshiki Kusama
Jan 20, 2009·Geriatrics & Gerontology International·Takashi OkamotoMasahiro Akishita
Dec 31, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Takumi KawaguchiMichio Sata
Jan 26, 2011·Expert Opinion on Therapeutic Targets·Niki KatsikiDimitrios Karamitsos
Jan 25, 2011·Diabetes Research and Clinical Practice·Naoto KatakamiYoshimitsu Yamasaki
Jul 4, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sanjay KalraLeszek Czupryniak
Jan 20, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Ying-Hua ChenBo Feng

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.