Efficacy of gonadotropin-releasing hormone agonist and an extended-interval dosing regimen in the treatment of patients with adenomyosis and endometriosis

Gynecologic and Obstetric Investigation
Jia-li KangXiao-hui Huang

Abstract

To determine the effects of gonadotropin-releasing hormone agonist (GnRH-a) and an extended-interval dosing regimen in the treatment of patients with adenomyosis and endometriosis. This was a prospective observational study in the setting of a hospital outpatient clinic. Seventy women suffering from adenomyosis and endometriosis were randomly divided into 2 groups: extended-interval dosing (experimental group) and conventional dosing (control group). Patients in the experimental group received a 4-dose regimen (triptorelin 3.75 mg by intramuscular injection every 6 weeks for a total of 4 doses). The patients in the control group received a conventional regimen (1 injection every 4 weeks for a total of 6 doses). The main outcome measures were relief and recurrence of dysmenorrhea and related climacteric symptoms, reduction of uterine volume, and serum levels of 17-beta-oestradiol (E(2)), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The reliving rate of dysmenorrhea was 100% in patients treated with both the new regimen and the convention regimen after 6 months. The uterine volume was reduced 37.6% and 39.2%, respectively. And the levels of LH, FSH and E(2) were decreased significantly (p < 0.001). The E(2 )l...Continue Reading

Citations

Jun 7, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Tetsuya HirataYutaka Osuga
May 17, 2014·Expert Opinion on Pharmacotherapy·Umberto Leone Roberti MaggioreSimone Ferrero
May 17, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Na DaiBao-Chan Pu
Apr 23, 2015·Gynécologie, obstétrique & fertilité·L PelageH Fernandez
Mar 20, 2018·The Journal of International Medical Research·Qing LiKe-Qin Hua
May 31, 2018·The Journal of Obstetrics and Gynaecology Research·Kazuaki NeriishiYutaka Osuga
Aug 21, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Elena Andreeva, Yulia Absatarova
May 21, 2015·Archives of Gynecology and Obstetrics·Muhammad Fawzy, Yasser Mesbah
Jul 1, 2020·Expert Opinion on Drug Metabolism & Toxicology·Luigi Della CortePierluigi Giampaolino
Oct 31, 2020·Seminars in Reproductive Medicine·Adela G CopeElizabeth A Stewart
May 20, 2021·Minerva Obstetrics and Gynecology·Simona MartoneStefano Luisi
Sep 3, 2010·Current Opinion in Obstetrics & Gynecology

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