PMID: 2508418Jan 1, 1989Paper

Efficacy of gonadotropin-releasing hormone agonist (buserelin) in the treatment of endometriosis

Acta Obstetricia Et Gynecologica Scandinavica
L RönnbergJ Saastamoinen

Abstract

In a multicenter study, the efficacy of and tolerance of 6 months' intranasal gonadotropin-releasing hormone agonist (buserelin) treatment (300 micrograms x 3/day) on laparoscopically verified endometriosis was evaluated in 25 patients. At second-look laparoscopy at the end of medication, the mean endometriosis score had fallen by 82.2%. All endometriosis-associated symptoms and physical findings decreased or almost disappeared during buserelin administration. After discontinuing therapy, they showed a tendency to reappear, but nevertheless they were milder after one year of follow-up, than before treatment. Seven (54%) of the 13 women wishing pregnancy actually conceived. Vaginal irregular spotting bleedings during the first 2 months occurred in 7 patients. No patient withdrew from the trial because of side effects, although almost all women developed symptoms of estrogen deficiency (serum estradiol concentrations fell to menopausal levels).

Citations

Nov 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Goulding, L Fisher
Nov 1, 1993·Breast Cancer Research and Treatment·D V Spicer, M C Pike
Sep 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M A Damario, J A Rock
Feb 1, 1996·The Journal of the American Association of Gynecologic Laparoscopists·A J DulebaD L Olive

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