Efficacy of green nanoparticles against cancerous and normal cell lines: a systematic review and meta-analysis

IET Nanobiotechnology
Hamed BarabadiMuthupandian Saravanan

Abstract

This study aimed to perform a systematic review and meta-analysis of papers discussing the efficacy of microbial synthesised metallic nanoparticles (MNPs) against cancerous and normal cell lines by exploiting Bayesian generalised linear (BGL) model. Data was systematically collected from published papers via Cochrane library, Web of Science, PubMed, Science Direct, ProQuest, Scopus, and Embase. Impressively, most of the studies were carried out on HeLa and A549 cancer cell lines. Specifically, a hefty 65.67% of studies employed bacteria to biofabricate MNPs. Significantly, BGL meta-analysis represented highly valuable information. Hence, based on adjusted analysis, the MNPs with the size of 25-50 nm were found to be far less cytotoxic than the MNPs with the size of ≤25 nm (OR = 0.233, P ˂ 0.05) against either cancerous or normal cell lines. Interestingly, it was found that the odds of cytotoxicity in cancerous cell lines were practically nine times more than normal cell lines, representing the substantially more cytotoxicity of MNPs in cancerous cell lines (OR = 9.004, P ˂ 0.001). Green MNPs mentioned here may be developed as novel anti-cancer agents, which could lead to a revolution in the treatment of cancer.

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Citations

Jun 9, 2018·Applied Microbiology and Biotechnology·Muhammad OvaisSudip Mukherjee
Mar 29, 2018·Applied Microbiology and Biotechnology·Muhammad OvaisZabta Khan Shinwari
Oct 17, 2019·Microscopy Research and Technique·Nosheen FerozeAsma Ayaz
Nov 28, 2019·Biomolecules·Bahare SalehiJavad Sharifi-Rad
Nov 9, 2018·Frontiers in Aging Neuroscience·Muhammad OvaisZabta Khan Shinwari

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