Efficacy of heat and moisture exchangers in preventing ventilator-associated pneumonia: meta-analysis of randomized controlled trials

Intensive Care Medicine
Axel KolaPetra Gastmeier

Abstract

Several randomized controlled trials (RCT) have examined the effect of antibacterial humidification strategies, particularly the replacement of heated humidifiers (HH) by heat and moisture exchangers (HME), in preventing ventilator-associated pneumonia (VAP). The present meta-analysis reviews these RCTs. RCTs were identified by searching the Medline and Cochrane Central Register of Controlled Trials databases from 1990 to 2003. We included RCTs using HMEs in the treatment group and HHs in the control group and reporting the incidence of pneumonia as a study outcome. Two investigators independently abstracted key data on design, population, intervention and outcome of the studies. Between 1990 and 2003 eight RCTs met the inclusion criteria of this analysis. Pooling the results from these studies revealed a reduction in the relative risk of VAP in the HME group (0.7), particularly in MV with a duration of at least 7 days (five RCTs, relative risk 0.57). This meta-analysis found a significant reduction in the incidence of VAP in patients humidified with HMEs during MV, particularly in patients ventilated for 7 days or longer. This finding is limited by the exclusion of patients at high risk for airway occlusion from some of the st...Continue Reading

References

Mar 21, 1998·JAMA : the Journal of the American Medical Association·D CookC Brun-Buisson
Feb 25, 1999·The New England Journal of Medicine·M H Kollef
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·J D RicardD Dreyfuss
Mar 21, 2002·Critical Care Medicine·Laurent ThomachotClaude Martin
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Jean Chastre, Jean-Yves Fagon
Apr 9, 2002·Journal of Chemotherapy·J L VincentM Struelens
Nov 26, 2002·Intensive Care Medicine·Sebastian PrinAntoine Vieillard-Baron
Apr 23, 2003·Intensive & Critical Care Nursing : the Official Journal of the British Association of Critical Care Nurses·Suzanne Bench
Jul 31, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Irina ZuschneidPetra Gastmeier
Jul 31, 2003·American Journal of Infection Control·Petra GastmeierHenning Rüden
Sep 16, 2003·Critical Care Medicine·Leonardo LorenteAntonio Sierra

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Citations

Aug 30, 2005·American Journal of Respiratory and Critical Care Medicine·Jean-Claude LacheradeLaurent Brochard
May 8, 2010·American Journal of Respiratory and Critical Care Medicine·Leonardo LorenteJordi Rello
Aug 4, 2006·Critical Care : the Official Journal of the Critical Care Forum·Leonardo LorenteAntonio Sierra
Oct 10, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M Auxiliadora-MartinsA Basile-Filho
Mar 7, 2014·Medicina intensiva·F Álvarez LermaUNKNOWN Sociedad Española de Enfermería Intensiva
Apr 10, 2013·Irish Journal of Medical Science·S Oğuz, I Değer
Apr 3, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N JoramC Gras-Le Guen
Mar 29, 2011·Journal of Critical Care·Alex DoylePeter Young
May 15, 2010·Medicina intensiva·E DiazJ Rello
Apr 28, 2009·Infectious Disease Clinics of North America·Ilias I SiemposMatthew E Falagas
Aug 28, 2007·The Journal of Hospital Infection·P Gastmeier, C Geffers
Mar 31, 2007·Clinics in Perinatology·Andreas Schulze
Nov 21, 2014·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Jul 21, 2006·Journal of Intensive Care Medicine·Kimberly A Davis
Sep 15, 2017·The Cochrane Database of Systematic Reviews·Donna GilliesBisanth T Batuwitage
Aug 28, 2015·The Open Respiratory Medicine Journal·F CerpaJ Keymer
Mar 13, 2012·Hospital Practice·Madiha Ashraf, Luis Ostrosky-Zeichner
Nov 16, 2016·Anesthesiology and Pain Medicine·Mayra Goncalves MeneguetiAltacilio Aparecido Nunes

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