Efficacy of Helicobacter pylori eradication regimens in Rwanda: a randomized controlled trial

BMC Gastroenterology
Jean Damascene KabakambiraTim Walker

Abstract

Successful H. pylori treatment requires the knowledge of local antimicrobial resistance. Data on the efficacy of H. pylori eradication regimens available in sub-Saharan Africa are scant, hence the optimal treatment is unknown. Our goals were to determine the efficacy of available regimens in Rwanda as well as evaluate the effect of treatment on health-related quality of life (HRQoL) in patients undergoing esophagogastroduodenoscopy. This is a randomized controlled trial conducted from November 2015 to October 2016 at a tertiary hospital in Rwanda. Enrollees were 299 patients (35% male, age 42 ± 16 years (mean ± SD)) who had a positive modified rapid urease test on endoscopic biopsies. After a fecal antigen test (FAT) and HRQoL assessment by the Short Form Nepean Dyspepsia Index (SF-NDI) questionnaire, patients were randomized 1:1:1:1 to either a triple therapy combining omeprazole, amoxicillin and one of clarithromycin/ciprofloxacin/metronidazole or a quadruple therapy combining omeprazole, amoxicillin, ciprofloxacin and doxycycline. All therapies were given for a duration of 10 days. The outcome measures were the persistence of positive FAT (treatment failure) 4 to 6 weeks after treatment and change in HRQoL scores. The treatm...Continue Reading

References

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Citations

Jul 25, 2019·World Journal of Gastroenterology : WJG·Stella SmithRinaldo Pellicano
Sep 6, 2019·Helicobacter·Anthony O'ConnorColm O'Morain
Sep 6, 2019·Helicobacter·Doron BoltinChristian Schulz

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BETA
biopsy
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pregnancy test

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CIPRO
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