Efficacy of hepatic resection vs transarterial chemoembolization for solitary huge hepatocellular carcinoma

World Journal of Gastroenterology : WJG
Shao-Liang ZhuLequn Li

Abstract

To compare the efficacy of hepatic resection (HR) and transarterial chemoembolization (TACE) for patients with solitary huge (≥ 10 cm) hepatocellular carcinoma (HCC). Records were retrospectively analyzed of 247 patients with solitary huge HCC, comprising 180 treated by HR and 67 by TACE. Long-term overall survival (OS) was compared between the two groups using the Kaplan-Meier method, and independent predictors of survival were identified by multivariate analysis. These analyses were performed using all patients in both groups and/or 61 pairs of propensity score-matched patients from the two groups. OS at 5 years was significantly higher in the HR group than the TACE group, across all patients (P = 0.002) and across propensity score-matched pairs (36.4% vs 18.2%, P = 0.039). The two groups showed similar postoperative mortality and morbidity. Multivariate analysis identified alpha-fetoprotein ≥ 400 ng/mL, presence of vascular invasion and TACE treatment as independent predictors of poor OS. Our findings suggest that HR can be safe and more effective than TACE for patients with solitary huge HCC.

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Citations

Aug 30, 2016·World Journal of Gastroenterology : WJG·Jeong Il Yu, Hee Chul Park
Mar 26, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shiro MiyayamaKazuo Notsumata
Jan 9, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Zixiang ChenFubao Liu
Jan 19, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Han WangWen-Ming Cong
Dec 22, 2020·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Andrea ChiericiAntonio Facciorusso

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