Efficacy of high-flow nasal cannula therapy in bedridden patients.

Pediatrics International : Official Journal of the Japan Pediatric Society
Kenji InoueSusumu Ohno

Abstract

A growing number of studies have demonstrated the efficacy of high-flow nasal cannula therapy (HFNC) for treating children with acute respiratory distress. However, it remains unknown whether HFNC is effective in bedridden patients with acute respiratory distress. We retrospectively reviewed the medical records of bedridden patients with acute respiratory distress that were treated with HFNC using a home ventilator in continuous positive airway pressure (CPAP) mode at our center between March 2014 and August 2016. We assessed heart rate (HR), respiratory rate (RR), oxygen saturation measured using a pulse oximeter (SpO2 ), the partial pressure of venous carbon dioxide (PvCO2 ) or the transcutaneous partial pressure of carbon dioxide (TcPCO2 ), and symptoms of respiratory distress before and after the initiation of HFNC. During the two-year-study period, 25 patients were treated with HFNC. The patients' mean HR, RR, SpO2 , and PvCO2 /TcPCO2 values improved significantly (p <0.05). Symptoms of respiratory distress considerably ameliorated at 1-3 hours after the HFNC initiation, except in 2 patients. In these 2 patients, the HFNC was replaced with non-invasive positive pressure ventilation (NPPV). NPPV was also required at 16 to 1...Continue Reading

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