Efficacy of high-flow oxygen therapy in all types of headache: a prospective, randomized, placebo-controlled trial

The American Journal of Emergency Medicine
Birsen OzkurtTroy Madsen

Abstract

We aimed to assess the efficacy of oxygen inhalation therapy in emergency department (ED) patients presenting with all types of headache. We performed a prospective, randomized, double-blinded, placebo-controlled trial of patients presenting to the ED with a chief complaint of headache. The patients were randomized to receive either 100% oxygen via nonrebreather mask at 15 L/min or the placebo treatment of room air via nonrebreather mask for 15 minutes in total. We recorded pain scores at 0, 15, 30, and 60 minutes using the visual analog scale. At 30 minutes, the patients were assessed for the need for analgesic medication. Patient headache type was classified by the treating emergency physician using standardized diagnostic criteria. A total of 204 patients agreed to participate in the study and were randomized to the oxygen (102 patients) and placebo (102 patients) groups. Patient headache types included tension (47%), migraine (27%), undifferentiated (25%), and cluster (1%). Patients who received oxygen therapy reported significant improvement in visual analog scale scores at all points when compared with placebo: 22 mm vs 11 mm at 15 minutes (P < .001), 29 mm vs 13 mm at 30 minutes (P < .001), and 55 mm vs 45 mm at 60 minut...Continue Reading

References

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Citations

Aug 3, 2013·Practical Neurology·Heather Angus-Leppan
Jan 28, 2014·Archivos de bronconeumología·Francisco Ortega RuizJulia Tàrrega Camarasa
Jul 18, 2015·Toxins·Sara M SchaeferBahman Jabbari
Oct 1, 2013·The Journal of Emergency Medicine·Carlos J Roldan
Apr 12, 2013·The Journal of Headache and Pain·Tim P JürgensArne May
May 22, 2016·Cephalalgia : an International Journal of Headache·Aneesh B SinghalMehmet A Topcuoglu
Apr 12, 2014·Cephalalgia : an International Journal of Headache·Anja S PetersenRigmor H Jensen
Mar 16, 2018·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Jeffrey T SakamotoStephanie A Eucker
Jul 19, 2018·Cephalalgia : an International Journal of Headache·Susan M Seav, Nathaniel M Schuster
Mar 30, 2019·Expert Opinion on Drug Discovery·Nicolas Vandenbussche, Peter J Goadsby
Dec 29, 2015·The Cochrane Database of Systematic Reviews·Michael H BennettStephanie Weibel
May 17, 2017·Thorax·B R O'DriscollUNKNOWN BTS Emergency Oxygen Guideline Development Group
Feb 27, 2021·Cephalalgia : an International Journal of Headache·Rushil ShahNauman Tariq
Jun 20, 2021·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Todd V CarteeVineet Mishra
Sep 21, 2017·The American Journal of Emergency Medicine·Danya KhoujahMichael K Abraham

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