Efficacy of high-intensity, low-volume interval training compared to continuous aerobic training on insulin resistance, skeletal muscle structure and function in adults with metabolic syndrome: study protocol for a randomized controlled clinical trial (Intraining-MET)

Trials
Jaime Gallo-VillegasJuan C Calderón

Abstract

Evidence of the efficacy of high-intensity, low-volume interval training (HIIT-low volume) in treating insulin resistance (IR) in patients with metabolic disorders is contradictory. In addition, it is unknown whether this effect is mediated through muscle endocrine function, which in turn depends on muscle mass and fiber type composition. Our aims were to assess the efficacy of HIIT-low volume compared to continuous aerobic exercise (CAE) in treating IR in adults with metabolic syndrome (MS) and to establish whether musclin, apelin, muscle mass and muscle composition are mediators of the effect. This is a controlled, randomized, clinical trial using the minimization method, with blinding of those who will evaluate the outcomes and two parallel groups for the purpose of showing superiority. Sixty patients with MS and IR with ages between 40 and 60 years will be included. A clinical evaluation will be carried out, along with laboratory tests to evaluate IR (homeostatic model assessment (HOMA)), muscle endocrine function (serum levels of musclin and apelin), thigh muscle mass (by dual energy x-ray absorptiometry (DXA) and thigh muscle composition (by carnosine measurement with proton magnetic resonance spectroscopy (1H-MRS)), befo...Continue Reading

Associated Clinical Trials

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Citations

Nov 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Carlos CastañoMarcelina Párrizas
Jun 27, 2021·European Journal of Pharmacology·Jingshun LuoLinxi Chen

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Methods Mentioned

BETA
sandwich immunoassay
enzyme
ELISA
x-ray

Software Mentioned

Minimpy®
STATA
Hologic APEX
SPSS Statistics
jMRUI
SPIRIT
SyngoMR D13

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