Efficacy of high zinc biofortified wheat in improvement of micronutrient status, and prevention of morbidity among preschool children and women - a double masked, randomized, controlled trial

Nutrition Journal
Sunil SazawalAshish Prakash

Abstract

Biofortification of staple food crops with zinc (Zn) can be one of the cost-effective and sustainable strategies to combat zinc deficiency and prevent morbidity among the target population. Agronomic approaches such as application of Zn fertilizers to soil and/or foliar spray seem to be a practical tool for Zn biofortification of wheat. However, there is a need to evaluate its efficacy from randomized controlled trials. This study aimed to evaluate the efficacy of zinc biofortified wheat flour on zinc status and its impact on morbidity among children aged 4-6 years and non-pregnant non lactating woman of child bearing age (WCBA) in Delhi, India. In a community based, double-masked randomized controlled trial, 6005 participants (WCBA and child pairs) were enrolled and randomly allocated to receive either high zinc biofortified wheat flour (HZn, 30 ppm zinc daily) or low zinc biofortified wheat flour (LZn, 20 ppm zinc daily) for 6 months (WCBA @ 360 g/day and children @ 120 g/day). Baseline and endline blood samples were obtained for assessing hematological markers; zinc status and data on compliance and morbidity were collected. Compliance rates were high; ~ 88% of the WCBAs in both the groups consumed 50% or more of recommended...Continue Reading

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Citations

Jul 7, 2020·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·S GuptaN M Lowe
Sep 19, 2020·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Shagufta PerveenNaeem Iqbal
Feb 18, 2021·Food and Nutrition Bulletin·Jennifer K FoleyErick Boy

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