PMID: 11901656Mar 21, 2002Paper

Efficacy of highly active antiretroviral therapy in HIV-1 infected children

The Lancet Infectious Diseases
Annemarie M C van RossumRonald de Groot

Abstract

Although the reduction in HIV-1-related deaths with highly active antiretroviral therapy (HAART) is similar in adults and children, the extent of the changes in two important surrogate markers HIV-1 RNA levels and CD4+ T cell counts, differs widely. In most paediatric studies virological response rates to HAART are inferior to those in adults. This review provides an overview of the paediatric clinical studies using HAART and seeks to improve the understanding of factors that may contribute to success or failure of HAART in children. An overview of all current articles on paediatric clinical trials using HAART is provided. 23 papers were available. HIV-1 RNA loads and CD4+ T cell counts were used as primary outcome measures. Virological response rates were highly variable, both among the different antiretroviral drugs but also among different studies using the same medication. Four studies in which dosages of the administrated protease inhibitor (PI) were adjusted after pharmacokinetic evaluation had superior virological response rates compared with those in which fixed dosages were used. Immunological response rates were more uniform than virological responses. In almost all studies increases of CD4+ T cell counts are reported...Continue Reading

References

Jan 19, 1995·The New England Journal of Medicine·C L MackallS M Steinberg
Mar 1, 1997·The Journal of Pediatrics·W M Comans-BitterJ J van Dongen
Mar 21, 1998·JAMA : the Journal of the American Medical Association·P E PalumboC J Baker
May 4, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A J MelvinL M Frenkel
Aug 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P KrogstadY Bryson
Jan 21, 2000·Pharmacotherapy·R B QaqishD A Wohl
Feb 19, 2000·Antimicrobial Agents and Chemotherapy·G GattiN Principi
Apr 14, 2000·The Journal of Infectious Diseases·D C DouekK Luzuriaga

❮ Previous
Next ❯

Citations

Jan 15, 2005·European Journal of Pediatrics·Ana María Sánchez TorresMaría Isabel De José Gómez
Jun 23, 2006·AIDS and Behavior·Winnie Bikaako-KajuraRebecca Bunnell
Aug 11, 2005·Current HIV/AIDS Reports·Jennifer J KiserJohn G Gerber
Jul 29, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Peter BockBrian Eley
Jan 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rangsima LolekhaJintanat Ananworanich
Feb 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pieter L A FraaijRonald de Groot
Nov 18, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andrea L CiaranelloRochelle P Walensky
May 19, 2009·International Journal of Epidemiology·Andrew EdmondsFrieda Behets
Apr 21, 2004·AIDS·Damien BonnetStéphane Blanche
May 30, 2006·The Pediatric Infectious Disease Journal·Kristel M L CrommentuynJos H Beijnen
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Mark Hatherill
Sep 24, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Constance DelaugerreStéphane Blanche
Apr 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Alina S BergshoeffDavid M Burger
May 15, 2012·The Pediatric Infectious Disease Journal·Adeodata KekitiinwaFrank M Graziano
Jul 13, 2012·The Pediatric Infectious Disease Journal·Miguel de MulderAfrica Holguin
Apr 26, 2007·AIDS·H GreenUNKNOWN Paediatric European Network for the Treatment of AIDS (PENTA)
Apr 23, 2008·AIDS·Anand Reddi, Sarah C Leeper
Dec 17, 2009·AIDS·UNKNOWN Paediatric European Network for Treatment of AIDS
Mar 16, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Dalton C WamalwaGrace John-Stewart
Apr 2, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Bhavna H ChohanDalton C Wamalwa
May 2, 2009·Current Opinion in Infectious Diseases·Ravindra K GuptaDeenan Pillay
Jun 3, 2010·Antimicrobial Agents and Chemotherapy·Naïm BouazzaSaik Urien
Jan 4, 2013·PloS One·Miguel de MulderUNKNOWN Madrid Cohort of HIV-Infected Children
Aug 27, 2009·Therapeutics and Clinical Risk Management·Susan J Schuval
Apr 28, 2007·American Journal of Public Health·Patricia MyungJohn Tucker
Feb 7, 2016·Indian Journal of Pediatrics·Mamatha M Lala, Rashid H Merchant

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.