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Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent

Biochemical Pharmacology

May 1, 2007

Rami G AzrakYoucef M Rustum

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Abstract

This study was designed to understand the basis for the efficacy of methylselenocysteine (MSC) in increasing the therapeutic index of irinotecan against human tumor xenografts. Nude mice bearing human head and neck squamous cells carcinoma xenografts (FaDu and A253) were treated orally ...read more

Mentioned in this Paper

Bone Marrow
Camptothecin
Malignant Neoplasms
Carcinoma
Cell Differentiation Process
Dose-Response Relationship, Drug
Epidemiology
Fluorouracil
Fresh Frozen Plasma
Large Intestine
Paper Details
References
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  • Citations10
12
  • References11
  • Citations10
1

Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent

Biochemical Pharmacology

May 1, 2007

Rami G AzrakYoucef M Rustum

PMID: 17239826

DOI: 10.1016/j.bcp.2006.12.020

Abstract

This study was designed to understand the basis for the efficacy of methylselenocysteine (MSC) in increasing the therapeutic index of irinotecan against human tumor xenografts. Nude mice bearing human head and neck squamous cells carcinoma xenografts (FaDu and A253) were treated orally ...read more

Mentioned in this Paper

Bone Marrow
Camptothecin
Malignant Neoplasms
Carcinoma
Cell Differentiation Process

Related Papers

Paper Details
References
  • References11
  • Citations10
12
  • References11
  • Citations10
1

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