Efficacy of inhaled prostanoids in experimental pulmonary hypertension

Critical Care Medicine
M KleenB Zwissler

Abstract

To evaluate the effects of inhaled prostacyclin (PGI2) and inhaled as well as intravenous prostaglandin E1 (PGE1) on thromboxane A2 mimetic-induced pulmonary vasoconstriction. Active pulmonary vasoconstriction was to be distinguished from passive resistance to blood flow. Prospective, randomized, crossover study. Experimental animal laboratory. Eight anesthetized and paralyzed sheep. The stable thromboxane A2 mimetic, U46619, was infused in increasing dosage to obtain a stable pulmonary hypertension of approximately 30 mm Hg. Subsequently, PGE1 aerosol (0.6, 6, 58, 259 ng/kg/min), intravenous PGE, (0.5 microg/kg/min), or PGI2 aerosol (27 ng/kg/min) were administered in randomized order. Active pulmonary vasoconstriction was assessed by determining the pulmonary pressure-flow relationship (PPFR). For measurement of pulmonary artery flow, an ultrasound flow probe was placed around the pulmonary artery after a sternotomy. Pulmonary arterial pressure was measured with a pulmonary artery flotation catheter. Flow was varied by partial occlusion of the inferior vena cava or incremental opening of an arterio-venous fistula between the large neck vessels. The primary end points were the slope of the resulting linear pressure-flow relati...Continue Reading

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Citations

Jun 1, 1999·Current Opinion in Pediatrics·C L Dent, J J Pérez Fontán
Nov 26, 1999·Current Opinion in Pulmonary Medicine·C L Dent, Perez Fontan JJ
Aug 4, 2009·Pulmonary Pharmacology & Therapeutics·Hanno H LeuchteJürgen Behr
Aug 10, 2002·Anesthesiology·Stuart M Lowson
Mar 30, 2005·International Anesthesiology Clinics·John G Augoustides, E Andrew Ochroch
Aug 14, 2020·International Journal of Toxicology·Jeffrey TepperAndrew Clark

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