Efficacy of interleukin-6 in combination with D-dimer in predicting early poor postoperative prognosis after acute stanford type a aortic dissection

Journal of Cardiothoracic Surgery
Qingsong WuLinfeng Xie

Abstract

We studied early poor postoperative prognosis in acute Stanford type A aortic dissection (ATAAD) patients and investigated the predictive effect of interleukin-6 (IL-6) combined with D-dimer in the early poor postoperative prognosis after ATAAD. Data on 141 ATAAD patients, who underwent emergency surgery between January 2018 and December 2018 at our hospital, were studied. We analyzed early postoperative prognosis using two patient groups. Patients with good prognosis were included in group A and those with poor prognosis were in group B. Univariate logistic and multivariable logistic regression analysis were performed for poor early postoperative prognosis. Preoperative IL-6 level was lower (57.8 ± 39.0 vs 211.0 ± 153.7 pg/mL, p < 0.001) and the D-dimer was also lower (7.3 ± 6.1 vs. 16.7 ± 5.8 μg/mL, p < 0.001) in group A than in B. The cut-off points, determined by the ROC curve, were preoperative IL-6 > 108 pg/mL (area under the curve: AUC = 0.901) and D-dimer > 14.0 μg/mL (AUC = 0.817). Univariate logistic regression analysis showed that IL-6 > 108 pg/mL, D-dimer > 14.0 μg/mL, prothrombin time > 15 s, creatinine > 135 mmol/mL, and operation time > 306 min for ATAAD appeared to be early postoperative risk factors of poor pro...Continue Reading

References

May 13, 2003·Chest·Thomas WeberBernd Eber
Aug 18, 2004·Journal of the American College of Cardiology·Holger EggebrechtRaimund Erbel
Dec 23, 2006·The Annals of Thoracic Surgery·Vincenzo RampoldiUNKNOWN International Registry of Acute Aortic Dissection (IRAD) Investigators
Mar 14, 2007·The American Journal of Cardiology·Mark S HansenStuart J Hutchison
Nov 8, 2007·European Heart Journal·Gottfried SodeckAnton Laggner
Oct 5, 2011·Circulation·Kevin M HarrisUNKNOWN International Registry of Acute Aortic Dissection (IRAD) Investigators
Jul 31, 2013·Current Opinion in Hematology·Prabhakara Nagareddy, Susan S Smyth
Nov 28, 2013·The Journal of Thoracic and Cardiovascular Surgery·Liang-Wan ChenYi Dong
Jan 18, 2014·Annals of Medicine·Maria ProiettaFlavia Del Porto
Jan 20, 2015·The Journal of Thoracic and Cardiovascular Surgery·Liang-Wan ChenYi Dong
Feb 11, 2015·Lancet·Christoph A Nienaber, Rachel E Clough
Jul 25, 2017·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·A BroccaC Ronco
Apr 5, 2018·The Journal of Thoracic and Cardiovascular Surgery·Peter ChiuMichael P Fischbein
Jul 4, 2018·The Annals of Thoracic Surgery·Mehrdad GhoreishiBradley S Taylor
Jul 11, 2018·Journal of the American Heart Association·Ryo ItagakiAtsushi Yamaguchi
Aug 29, 2019·Journal of Intensive Care Medicine·Nicholas M Gourd, Nikitas Nikitas
Oct 28, 2019·Journal of Thoracic Disease·Miaoyun WenHongke Zeng

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.